Literature DB >> 22516874

Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin.

Jessica L Prodger1, Ronald Gray, Godfrey Kigozi, Fred Nalugoda, Ronald Galiwango, Kighoma Nehemiah, Moses Kakanga, Taha Hirbod, Maria J Wawer, Nelson Sewankambo, David Serwadda, Rupert Kaul.   

Abstract

Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4 T cells, which may contribute to HIV susceptibility.

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Year:  2012        PMID： 22516874      PMCID： PMC4241749          DOI： 10.1097/QAD.0b013e328354675c

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  15 in total

1.  Improved performance of enzyme-linked immunosorbent assays and the effect of human immunodeficiency virus coinfection on the serologic detection of herpes simplex virus type 2 in Rakai, Uganda.

Authors:  Jordyn L Gamiel; Aaron A R Tobian; Oliver B Laeyendecker; Steven J Reynolds; Rhoda Ashley Morrow; David Serwadda; Ronald H Gray; Thomas C Quinn
Journal:  Clin Vaccine Immunol       Date:  2008-03-05

2.  Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection.

Authors:  Aimee El Hed; Alka Khaitan; Lina Kozhaya; Nicolas Manel; Demetre Daskalakis; William Borkowsky; Fred Valentine; Dan R Littman; Derya Unutmaz
Journal:  J Infect Dis       Date:  2010-03-15       Impact factor: 5.226

3.  Effects of HIV-1 and herpes simplex virus type 2 infection on lymphocyte and dendritic cell density in adult foreskins from Rakai, Uganda.

Authors:  Kristine E Johnson; Andrew D Redd; Thomas C Quinn; Aleisha N Collinson-Streng; Toby Cornish; Xiangrong Kong; Rajni Sharma; Aaron A R Tobian; Benjamin Tsai; Mark E Sherman; Godfrey Kigozi; David Serwadda; Maria J Wawer; Ronald H Gray
Journal:  J Infect Dis       Date:  2011-01-10       Impact factor: 5.226

4.  Heterogeneity in host HIV susceptibility as a potential contributor to recent HIV prevalence declines in Africa.

Authors:  Nico Nagelkerke; Sake J de Vlas; Prabhat Jha; Ma Luo; Francis A Plummer; Rupert Kaul
Journal:  AIDS       Date:  2009-01-02       Impact factor: 4.177

5.  Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial.

Authors:  Connie Celum; Anna Wald; James Hughes; Jorge Sanchez; Stewart Reid; Sinead Delany-Moretlwe; Frances Cowan; Martin Casapia; Abner Ortiz; Jonathan Fuchs; Susan Buchbinder; Beryl Koblin; Sheryl Zwerski; Scott Rose; Jing Wang; Lawrence Corey
Journal:  Lancet       Date:  2008-06-21       Impact factor: 79.321

6.  Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infection.

Authors:  Annie Gosselin; Patricia Monteiro; Nicolas Chomont; Felipe Diaz-Griffero; Elias A Said; Simone Fonseca; Vanessa Wacleche; Mohamed El-Far; Mohamed-Rachid Boulassel; Jean-Pierre Routy; Rafick-Pierre Sekaly; Petronela Ancuta
Journal:  J Immunol       Date:  2009-12-30       Impact factor: 5.422

Review 7.  Genital herpes simplex virus infections: clinical manifestations, course, and complications.

Authors:  L Corey; H G Adams; Z A Brown; K K Holmes
Journal:  Ann Intern Med       Date:  1983-06       Impact factor: 25.391

8.  Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells.

Authors:  Catherine M Card; Paul J McLaren; Charles Wachihi; Joshua Kimani; Francis A Plummer; Keith R Fowke
Journal:  J Infect Dis       Date:  2009-05-01       Impact factor: 5.226

Review 9.  Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies.

Authors:  Esther E Freeman; Helen A Weiss; Judith R Glynn; Pamela L Cross; James A Whitworth; Richard J Hayes
Journal:  AIDS       Date:  2006-01-02       Impact factor: 4.177

10.  Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition.

Authors:  Jia Zhu; Florian Hladik; Amanda Woodward; Alexis Klock; Tao Peng; Christine Johnston; Michael Remington; Amalia Magaret; David M Koelle; Anna Wald; Lawrence Corey
Journal:  Nat Med       Date:  2009-08-02       Impact factor: 53.440
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  19 in total

Review 1.  Biologic interactions between HSV-2 and HIV-1 and possible implications for HSV vaccine development.

Authors:  Joshua T Schiffer; Sami L Gottlieb
Journal:  Vaccine       Date:  2017-09-25       Impact factor: 3.641

Review 2.  Inflammation and HIV Transmission in Sub-Saharan Africa.

Authors:  Rupert Kaul; Jessica Prodger; Vineet Joag; Brett Shannon; Sergey Yegorov; Ronald Galiwango; Lyle McKinnon
Journal:  Curr HIV/AIDS Rep       Date:  2015-06       Impact factor: 5.071

3.  Pre-exposure prophylaxis differentially alters circulating and mucosal immune cell activation in herpes simplex virus type 2 seropositive women.

Authors:  Laura E Richert-Spuhler; Laura Pattacini; Margot Plews; Elizabeth Irungu; Timothy R Muwonge; Elly Katabira; Nelly Mugo; Adrienne F A Meyers; Connie Celum; Jared M Baeten; Jairam R Lingappa; Jennifer M Lund
Journal:  AIDS       Date:  2019-11-15       Impact factor: 4.177

4.  Distinct Effects of the Cervicovaginal Microbiota and Herpes Simplex Type 2 Infection on Female Genital Tract Immunology.

Authors:  B Shannon; P Gajer; T J Yi; B Ma; M S Humphrys; J Thomas-Pavanel; L Chieza; P Janakiram; M Saunders; W Tharao; S Huibner; K Shahabi; J Ravel; R Kaul
Journal:  J Infect Dis       Date:  2017-05-01       Impact factor: 5.226

Review 5.  The Penis, the Vagina and HIV Risk: Key Differences (Aside from the Obvious).

Authors:  Rupert Kaul; Cindy M Liu; Daniel E Park; Ronald M Galiwango; Aaron A R Tobian; Jessica L Prodger
Journal:  Viruses       Date:  2022-05-27       Impact factor: 5.818

Review 6.  Does HIV Exploit the Inflammatory Milieu of the Male Genital Tract for Successful Infection?

Authors:  Rachel T Esra; Abraham J Olivier; Jo-Ann S Passmore; Heather B Jaspan; Rushil Harryparsad; Clive M Gray
Journal:  Front Immunol       Date:  2016-06-24       Impact factor: 7.561

7.  HIV Infection in Uncircumcised Men Is Associated With Altered CD8 T-cell Function But Normal CD4 T-cell Numbers in the Foreskin.

Authors:  Jessica L Prodger; Taha Hirbod; Ronald Gray; Godfrey Kigozi; Fred Nalugoda; Ronald Galiwango; Steven J Reynolds; Sanja Huibner; Maria J Wawer; David Serwadda; Rupert Kaul
Journal:  J Infect Dis       Date:  2013-11-25       Impact factor: 5.226

8.  Penile bacteria associated with HIV seroconversion, inflammation, and immune cells.

Authors:  Jessica L Prodger; Alison G Abraham; Aaron Ar Tobian; Daniel E Park; Maliha Aziz; Kelsey Roach; Ronald H Gray; Lane Buchanan; Godfrey Kigozi; Ronald M Galiwango; Joseph Ssekasanvu; James Nnamutete; Joseph Kagaayi; Rupert Kaul; Cindy M Liu
Journal:  JCI Insight       Date:  2021-04-22

9.  Immune correlates of HIV exposure without infection in foreskins of men from Rakai, Uganda.

Authors:  J L Prodger; T Hirbod; G Kigozi; F Nalugoda; S J Reynolds; R Galiwango; K Shahabi; D Serwadda; M J Wawer; R H Gray; R Kaul
Journal:  Mucosal Immunol       Date:  2013-10-23       Impact factor: 7.313

10.  Schistosoma mansoni Infection in Ugandan Men Is Associated with Increased Abundance and Function of HIV Target Cells in Blood, but Not the Foreskin: A Cross-sectional Study.

Authors:  Jessica L Prodger; Aloysious Ssemaganda; Ali Ssetaala; Paul K Kitandwe; Enoch Muyanja; Juliet Mpendo; Annet Nanvubya; Mathias Wambuzi; Leslie Nielsen; Noah Kiwanuka; Rupert Kaul
Journal:  PLoS Negl Trop Dis       Date:  2015-09-03
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