| Literature DB >> 22516304 |
Jianyong Li1, Yuanguang Yu, Yajun Yang, Xiwang Liu, Jiyu Zhang, Bing Li, Xuzheng Zhou, Jianrong Niu, Xiaojuan Wei, Zhiqi Liu.
Abstract
The subchronic toxicity of aspirin eugenol ester (AEE) was evaluated after 15-day intragastrically administration in rats at daily doses of 50, 1000, and 2000 mg/kg. AEE at low-dose showed no toxicity to the tested rats. Following repeated exposure to medium- or high-dose of AEE, apparent changes were observed in the levels of blood glucose, AST, ALP, ALT and TB in both male and female rats, and appeared to be dose-independent. There were no significant gender differences in most indexes of subchronic toxicity throughout the experimental period with the exception of food consumption and body weight. The no-observed-adverse-effect level (NOAEL) of AEE was considered to be 50 mg/kg/day under the present study conditions. CrownEntities:
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Year: 2012 PMID： 22516304 DOI： 10.1016/j.fct.2012.03.080
Source DB: PubMed Journal: Food Chem Toxicol ISSN： 0278-6915 Impact factor: 6.023