Literature DB >> 22516256

Personalized medicine: patient-predictive panel power.

Paul Workman1, Paul A Clarke, Bissan Al-Lazikani.   

Abstract

Two recent papers published in Nature demonstrate the power of systematic high-throughput pharmacologic profiling of very large, diverse, molecularly-characterized human cancer cell line panels to reveal linkages between genetic profile and targeted-drug sensitivity. Known oncogene addictions are confirmed while surprising complexities and biomarker relationships with clinical potential are revealed.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22516256     DOI： 10.1016/j.ccr.2012.03.030

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  6 in total

1.  Personalized medicine in neuro-oncology.

Authors:  Victor A Levin
Journal:  CNS Oncol       Date:  2016-03-21

Review 2.  Combinatorial drug therapy for cancer in the post-genomic era.

Authors:  Bissan Al-Lazikani; Udai Banerji; Paul Workman
Journal:  Nat Biotechnol       Date:  2012-07-10       Impact factor: 54.908

3.  A head and neck cancer tumor response-specific gene signature for cisplatin, 5-fluorouracil induction chemotherapy fails with added taxanes.

Authors:  Céline Tomkiewicz; Stéphane Hans; Marie Hélène Mucchielli; Nicolas Agier; Hervé Delacroix; Laetitia Marisa; Daniel Brasnu; Lawrence P Aggerbeck; Cécile Badoual; Robert Barouki; Martine Aggerbeck
Journal:  PLoS One       Date:  2012-10-09       Impact factor: 3.240

Review 4.  Drugging PI3K in cancer: refining targets and therapeutic strategies.

Authors:  Timothy A Yap; Lynn Bjerke; Paul A Clarke; Paul Workman
Journal:  Curr Opin Pharmacol       Date:  2015-06-25       Impact factor: 5.547

5.  Claudin-6: a novel receptor for CPE-mediated cytotoxicity in ovarian cancer.

Authors:  M Lal-Nag; M Battis; A D Santin; P J Morin
Journal:  Oncogenesis       Date:  2012-11-12       Impact factor: 7.485

6.  Predicting Anticancer Drug Responses Using a Dual-Layer Integrated Cell Line-Drug Network Model.

Authors:  Naiqian Zhang; Haiyun Wang; Yun Fang; Jun Wang; Xiaoqi Zheng; X Shirley Liu
Journal:  PLoS Comput Biol       Date:  2015-09-29       Impact factor: 4.475
  6 in total

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