Literature DB >> 22516197

The tumor suppressor merlin controls growth in its open state, and phosphorylation converts it to a less-active more-closed state.

Ifat Sher, C Oliver Hanemann, P Andrew Karplus, Anthony Bretscher.   

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Year:  2012        PMID： 22516197      PMCID： PMC3725555          DOI： 10.1016/j.devcel.2012.03.008

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


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  10 in total

1.  Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP.

Authors:  R Nguyen; D Reczek; A Bretscher
Journal:  J Biol Chem       Date:  2000-12-05       Impact factor: 5.157

Review 2.  ERM proteins and merlin: integrators at the cell cortex.

Authors:  Anthony Bretscher; Kevin Edwards; Richard G Fehon
Journal:  Nat Rev Mol Cell Biol       Date:  2002-08       Impact factor: 94.444

3.  Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain.

Authors:  Qianzhi Li; Mark R Nance; Rima Kulikauskas; Kevin Nyberg; Richard Fehon; P Andrew Karplus; Anthony Bretscher; John J G Tesmer
Journal:  J Mol Biol       Date:  2006-10-26       Impact factor: 5.469

4.  Defects in neurofibromatosis 2 protein function can arise at multiple levels.

Authors:  D H Gutmann; R T Geist; H m Xu; J S Kim; S Saporito-Irwin
Journal:  Hum Mol Genet       Date:  1998-03       Impact factor: 6.150

Review 5.  Organizing the cell cortex: the role of ERM proteins.

Authors:  Richard G Fehon; Andrea I McClatchey; Anthony Bretscher
Journal:  Nat Rev Mol Cell Biol       Date:  2010-04       Impact factor: 94.444

6.  The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

Authors:  R J Shaw; J G Paez; M Curto; A Yaktine; W M Pruitt; I Saotome; J P O'Bryan; V Gupta; N Ratner; C J Der; T Jacks; A I McClatchey
Journal:  Dev Cell       Date:  2001-07       Impact factor: 12.270

7.  Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function.

Authors:  Ezequiel I Surace; Carrie A Haipek; David H Gutmann
Journal:  Oncogene       Date:  2004-01-15       Impact factor: 9.867

8.  Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression.

Authors:  Rong Rong; Ezequiel I Surace; Carrie A Haipek; David H Gutmann; Keqiang Ye
Journal:  Oncogene       Date:  2004-11-04       Impact factor: 9.867

9.  A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration.

Authors:  Marianne F James; Roberta L Beauchamp; Nitasha Manchanda; Andrius Kazlauskas; Vijaya Ramesh
Journal:  J Cell Sci       Date:  2004-05-25       Impact factor: 5.285

10.  Contact-dependent inhibition of EGFR signaling by Nf2/Merlin.

Authors:  Marcello Curto; Banumathi K Cole; Dominique Lallemand; Ching-Hui Liu; Andrea I McClatchey
Journal:  J Cell Biol       Date:  2007-06-04       Impact factor: 10.539
  10 in total
  29 in total

1.  Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/β-Catenin Signaling.

Authors:  Ming Quan; Jiujie Cui; Tian Xia; Zhiliang Jia; Dacheng Xie; Daoyan Wei; Suyun Huang; Qian Huang; Shaojiang Zheng; Keping Xie
Journal:  Cancer Res       Date:  2015-10-19       Impact factor: 12.701

2.  Phosphorylation of Merlin by Aurora A kinase appears necessary for mitotic progression.

Authors:  Vinay Mandati; Laurence Del Maestro; Florent Dingli; Bérangère Lombard; Damarys Loew; Nicolas Molinie; Stephane Romero; Daniel Bouvard; Daniel Louvard; Alexis M Gautreau; Eric Pasmant; Dominique Lallemand
Journal:  J Biol Chem       Date:  2019-07-11       Impact factor: 5.157

3.  BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling.

Authors:  Sachin Verma; Narayana Yeddula; Yasushi Soda; Quan Zhu; Gerald Pao; James Moresco; Jolene K Diedrich; Audrey Hong; Steve Plouffe; Toshiro Moroishi; Kun-Liang Guan; Inder M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  2019-03-27       Impact factor: 11.205

4.  CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies.

Authors:  Brigitte C Widemann; Maria T Acosta; Sylvia Ammoun; Allan J Belzberg; Andre Bernards; Jaishri Blakeley; Antony Bretscher; Karen Cichowski; D Wade Clapp; Eva Dombi; Gareth D Evans; Rosalie Ferner; Cristina Fernandez-Valle; Michael J Fisher; Marco Giovannini; David H Gutmann; C Oliver Hanemann; Robert Hennigan; Susan Huson; David Ingram; Joe Kissil; Bruce R Korf; Eric Legius; Roger J Packer; Andrea I McClatchey; Frank McCormick; Kathryn North; Minja Pehrsson; Scott R Plotkin; Vijaya Ramesh; Nancy Ratner; Susann Schirmer; Larry Sherman; Elizabeth Schorry; David Stevenson; Douglas R Stewart; Nicole Ullrich; Annette C Bakker; Helen Morrison
Journal:  Am J Med Genet A       Date:  2014-01-17       Impact factor: 2.802

Review 5.  Control of cellular responses to mechanical cues through YAP/TAZ regulation.

Authors:  Ishani Dasgupta; Dannel McCollum
Journal:  J Biol Chem       Date:  2019-10-08       Impact factor: 5.157

6.  Merlin status regulates p75(NTR) expression and apoptotic signaling in Schwann cells following nerve injury.

Authors:  Iram Ahmad; Augusta Fernando; Richard Gurgel; J Jason Clark; Linjing Xu; Marlan R Hansen
Journal:  Neurobiol Dis       Date:  2015-06-06       Impact factor: 5.996

Review 7.  Molecular insights into NF2/Merlin tumor suppressor function.

Authors:  Jonathan Cooper; Filippo G Giancotti
Journal:  FEBS Lett       Date:  2014-04-12       Impact factor: 4.124

8.  Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation.

Authors:  M Kim; S Kim; S-H Lee; W Kim; M-J Sohn; H-S Kim; J Kim; E-H Jho
Journal:  Cell Death Differ       Date:  2016-06-10       Impact factor: 15.828

9.  Molecular conformation of the full-length tumor suppressor NF2/Merlin--a small-angle neutron scattering study.

Authors:  Jahan Ali Khajeh; Jeong Ho Ju; Moussoubaou Atchiba; Marc Allaire; Christopher Stanley; William T Heller; David J E Callaway; Zimei Bu
Journal:  J Mol Biol       Date:  2014-05-29       Impact factor: 5.469

10.  Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1.

Authors:  Youjun Li; Zhiyi Wei; Junyi Zhang; Zhou Yang; Mingjie Zhang
Journal:  J Biol Chem       Date:  2014-04-04       Impact factor: 5.157
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