Yuanyuan Bai1, Peng Zhang, Xiaoling Zhang, Jie Huang, Shengshou Hu, Yingjie Wei. 1. State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, PR China.
Abstract
BACKGROUND: We have observed increased expression of latent TGF-β binding protein (LTBP)-2 mRNA in human failing hearts. This study was aimed to further confirm LTBP-2 act as a novel marker in human acute heart failure. METHODS AND RESULTS: We demonstrated that median level of LTBP-2 in myocardial samples from heart failure patients was significantly elevated, and TGF-β1 significantly promoted LTBP-2 expression in neonatal rat cardiomyocytes. To investigate the potential of LTBP-2 as a biomarker to diagnose heart failure with reduced ejection fraction (HFREF), another cohort of 133 consecutive patients with dyspnea were enrolled. In receiver operating characteristic (ROC) curve analyses to detect HFREF, LTBP-2 achieved an area under curve (AUC) of 0.67 (95% confidence intervals (CI) 0.58-0.75), comparable to the diagnostic ability of NT-proBNP 0.68 (95% CI 0.59-0.77). CONCLUSION: The serum LTBP-2 levels might act as a promising biomarker in HFREF.
BACKGROUND: We have observed increased expression of latent TGF-β binding protein (LTBP)-2 mRNA in human failing hearts. This study was aimed to further confirm LTBP-2 act as a novel marker in human acute heart failure. METHODS AND RESULTS: We demonstrated that median level of LTBP-2 in myocardial samples from heart failurepatients was significantly elevated, and TGF-β1 significantly promoted LTBP-2 expression in neonatal rat cardiomyocytes. To investigate the potential of LTBP-2 as a biomarker to diagnose heart failure with reduced ejection fraction (HFREF), another cohort of 133 consecutive patients with dyspnea were enrolled. In receiver operating characteristic (ROC) curve analyses to detect HFREF, LTBP-2 achieved an area under curve (AUC) of 0.67 (95% confidence intervals (CI) 0.58-0.75), comparable to the diagnostic ability of NT-proBNP 0.68 (95% CI 0.59-0.77). CONCLUSION: The serum LTBP-2 levels might act as a promising biomarker in HFREF.
Authors: Francois Potus; Charles Colin Thomas Hindmarch; Kimberly J Dunham-Snary; Jeff Stafford; Stephen L Archer Journal: Int J Mol Sci Date: 2018-09-12 Impact factor: 5.923
Authors: Sabine Ameling; Gourav Bhardwaj; Elke Hammer; Daniel Beug; Leif Steil; Yvonne Reinke; Kerstin Weitmann; Markus Grube; Christiane Trimpert; Karin Klingel; Reinhard Kandolf; Wolfgang Hoffmann; Matthias Nauck; Marcus Dörr; Klaus Empen; Stephan B Felix; Uwe Völker Journal: Basic Res Cardiol Date: 2016-07-13 Impact factor: 17.165