Literature DB >> 2251339

Differential effects of apomorphine on prepulse inhibition of acoustic startle reflex in two rat strains.

G C Rigdon1.   

Abstract

Apomorphine disruption of prepulse inhibition (PPI) has been proposed as an animal model of sensorimotor gating deficits exhibited by schizophrenics. The effects of apomorphine on PPI of the acoustic startle reflex in male rats of Wistar and CD (Sprague-Dawley derived) strains were compared under identical test conditions. In Wistar rats, subcutaneous administration of 0.25-1.0 mg/kg apomorphine blocked PPI without affecting startle amplitude. In CD rats, apomorphine (0.3-3.0 mg/kg, SC) had no effect on PPI, but increased startle amplitude. Therefore, choice of rat strain is an important factor in the design of experiments studying apomorphine effects on PPI.

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Year:  1990        PMID： 2251339     DOI： 10.1007/bf02244115

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  5 in total

1.  Apomorphine disrupts the inhibition of acoustic startle induced by weak prepulses in rats.

Authors:  M Davis; R S Mansbach; N R Swerdlow; S Campeau; D L Braff; M A Geyer
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

2.  Prestimulus effects on human startle reflex in normals and schizophrenics.

Authors:  D Braff; C Stone; E Callaway; M Geyer; I Glick; L Bali
Journal:  Psychophysiology       Date:  1978-07       Impact factor: 4.016

Review 3.  Startle response models of sensorimotor gating and habituation deficits in schizophrenia.

Authors:  M A Geyer; N R Swerdlow; R S Mansbach; D L Braff
Journal:  Brain Res Bull       Date:  1990-09       Impact factor: 4.077

4.  Dopaminergic stimulation disrupts sensorimotor gating in the rat.

Authors:  R S Mansbach; M A Geyer; D L Braff
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

5.  Apomorphine, d-amphetamine, strychnine and yohimbine do not alter prepulse inhibition of the acoustic startle reflex.

Authors:  M Davis
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530
  5 in total
  17 in total

1.  Developmental markers of psychiatric disorders as identified by sensorimotor gating.

Authors:  Susan B. Powell; Mark A. Geyer
Journal:  Neurotox Res       Date:  2002 Aug-Sep       Impact factor: 3.911

2.  Heritable differences in the dopaminergic regulation of sensorimotor gating. II. Temporal, pharmacologic and generational analyses of apomorphine effects on prepulse inhibition.

Authors:  Neal R Swerdlow; Jody M Shoemaker; Pamela P Auerbach; Leia Pitcher; Jana Goins; Amanda Platten
Journal:  Psychopharmacology (Berl)       Date:  2003-05-21       Impact factor: 4.530

3.  Differential effects of antipsychotic and propsychotic drugs on prepulse inhibition and locomotor activity in Roman high- (RHA) and low-avoidance (RLA) rats.

Authors:  Ignasi Oliveras; Ana Sánchez-González; Daniel Sampedro-Viana; Maria Antonietta Piludu; Cristóbal Río-Alamos; Osvaldo Giorgi; Maria G Corda; Susana Aznar; Javier González-Maeso; Cristina Gerbolés; Gloria Blázquez; Toni Cañete; Adolf Tobeña; Alberto Fernández-Teruel
Journal:  Psychopharmacology (Berl)       Date:  2017-02-02       Impact factor: 4.530

4.  Differences in response to an acoustic startle stimulus among forty-six rat strains.

Authors:  J R Glowa; C T Hansen
Journal:  Behav Genet       Date:  1994-01       Impact factor: 2.805

5.  Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine.

Authors:  B K Lipska; N R Swerdlow; M A Geyer; G E Jaskiw; D L Braff; D R Weinberger
Journal:  Psychopharmacology (Berl)       Date:  1995-11       Impact factor: 4.530

Review 6.  Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next.

Authors:  Neal R Swerdlow; David L Braff; Mark A Geyer
Journal:  J Psychopharmacol       Date:  2016-08-18       Impact factor: 4.153

7.  The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice.

Authors:  R J Ralph; G B Varty; M A Kelly; Y M Wang; M G Caron; M Rubinstein; D K Grandy; M J Low; M A Geyer
Journal:  J Neurosci       Date:  1999-06-01       Impact factor: 6.167

8.  D1 and D2 dopamine receptor antagonists reverse prepulse inhibition deficits in an animal model of schizophrenia.

Authors:  D C Hoffman; H Donovan
Journal:  Psychopharmacology (Berl)       Date:  1994-08       Impact factor: 4.530

9.  The CB receptor agonist WIN 55,212-2 fails to elicit disruption of prepulse inhibition of the startle in Sprague-Dawley rats.

Authors:  Marco Bortolato; Gian Nicola Aru; Roberto Frau; Marco Orrù; Grant Christopher Luckey; Gianluca Boi; Gian Luigi Gessa
Journal:  Psychopharmacology (Berl)       Date:  2004-07-28       Impact factor: 4.530

10.  Differential effects of acute alcohol on prepulse inhibition and event-related potentials in adolescent and adult Wistar rats.

Authors:  Jerry P Pian; Jose R Criado; Cindy L Ehlers
Journal:  Alcohol Clin Exp Res       Date:  2008-09-25       Impact factor: 3.455
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