Akerke Baibergenova1, Scott Walsh. 1. Division of Dermatology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON. a.baibergenova@utoronto.ca
Abstract
BACKGROUND: Recent basic science research has revealed a decreased tissue expression of peroxisome proliferator-activated receptor (PPAR) γ in lichen planopilaris (LPP). Therefore, thiazolidinediones, being PPARγ agonists, could be used to treat LPP. METHODS: We followed 24 patients with LPP who were treated with oral pioglitazone hydrochloride. Improvement in LPP was defined as a decrease in or disappearance of symptoms and perifollicular erythema in the context of halted spread of old patches. RESULTS: Twenty of 24 patients were females. The average age was 52.5 years, and ages ranged from 22 to 70 years. Five of 24 patients have achieved remission; improvement was noted in half of the patients; there was no change in 3 patients; and 4 patients discontinued treatment due to side effects. Side effects were mild and included left calf pain, lightheadedness and nausea, dizziness, and hives. CONCLUSION: Use of thiazolidinediones might be a new promising venue of LPP treatment.
BACKGROUND: Recent basic science research has revealed a decreased tissue expression of peroxisome proliferator-activated receptor (PPAR) γ in lichen planopilaris (LPP). Therefore, thiazolidinediones, being PPARγ agonists, could be used to treat LPP. METHODS: We followed 24 patients with LPP who were treated with oral pioglitazone hydrochloride. Improvement in LPP was defined as a decrease in or disappearance of symptoms and perifollicular erythema in the context of halted spread of old patches. RESULTS: Twenty of 24 patients were females. The average age was 52.5 years, and ages ranged from 22 to 70 years. Five of 24 patients have achieved remission; improvement was noted in half of the patients; there was no change in 3 patients; and 4 patients discontinued treatment due to side effects. Side effects were mild and included left calfpain, lightheadedness and nausea, dizziness, and hives. CONCLUSION: Use of thiazolidinediones might be a new promising venue of LPP treatment.
Authors: T Vogt; C Thomas; J Reichrath; L Schilling; D Mawlood; R Christmann; B Loretz; U Schäfer; C-M Lehr; C Müller Journal: Hautarzt Date: 2018-02 Impact factor: 0.751
Authors: Patricia F Coogan; Traci N Bethea; Yvette C Cozier; Kimberly A Bertrand; Julie R Palmer; Lynn Rosenberg; Yolanda Lenzy Journal: Int J Womens Dermatol Date: 2019-06-06