| Literature DB >> 22512908 |
Stefanos Riganas1, Ioannis Papanastasiou, George B Foscolos, Andrew Tsotinis, Jean-Jacques Bourguignon, Guillaume Serin, Jean-François Mirjolet, Kostas Dimas, Vassilios N Kourafalos, Andreas Eleutheriades, Vassilios I Moutsos, Humaira Khan, Stavroula Georgakopoulou, Angeliki Zaniou, Margarita Prassa, Maria Theodoropoulou, Stavroula Pondiki, Alexandre Vamvakides.
Abstract
The synthesis of N-{4-[a-(1-adamantyl)benzyl]phenyl}piperazines 2a-e is described. The in vitro antiproliferative activity of most compounds against main cancer cell lines is significant. The σ(1), σ(2)-receptors and sodium channels binding affinity of compounds 2 were investigated. One of the most active analogs, 2a, had an interesting in vivo anticancer profile against the BxPC-3 and Mia-Paca-2 pancreas cancer cell lines with caspase-3 activation, which was associated with an anagelsic activity against the neuropathic pain.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22512908 DOI： 10.1016/j.bmc.2012.03.038
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641