Pascale Jadoul1, Jacques Donnez. 1. Université Catholique de Louvain, Institut de Recherche Experimentale et Clinique, Unité de Recherche GYNE, Department of Gynecology, Université Catholique de Louvain, Brussels, Belgium. pascale.jadoul@uclouvain.be
Abstract
PURPOSE OF REVIEW: This article sets out to review the literature on gonadal toxicity of bone marrow transplantation (BMT) in women, and preventive and curative actions available for girls and women facing BMT and infertility. FINDINGS: The real incidence of ovarian damage after BMT is difficult to assess. Series reporting ovarian function and pregnancies after BMT vary greatly in terms of endpoints, number of patients included, age at and indications for BMT, conditioning regimens and duration of follow-up. The risk of premature ovarian failure (POF) is very high, however, and increases with age and in case of BMT conditioning treatment with total body irradiation. Embryo, oocyte and ovarian cortex cryopreservation are effective fertility preservation methods that should be discussed with all girls and young women requiring BMT. SUMMARY: Despite a lack of literature on long-term follow-up of fertility after BMT in large populations, it is clear that the risk of ovarian damage and POF is very high. Fertility preservation options should therefore be discussed with all patients having to undergo BMT.
PURPOSE OF REVIEW: This article sets out to review the literature on gonadal toxicity of bone marrow transplantation (BMT) in women, and preventive and curative actions available for girls and women facing BMT and infertility. FINDINGS: The real incidence of ovarian damage after BMT is difficult to assess. Series reporting ovarian function and pregnancies after BMT vary greatly in terms of endpoints, number of patients included, age at and indications for BMT, conditioning regimens and duration of follow-up. The risk of premature ovarian failure (POF) is very high, however, and increases with age and in case of BMT conditioning treatment with total body irradiation. Embryo, oocyte and ovarian cortex cryopreservation are effective fertility preservation methods that should be discussed with all girls and young women requiring BMT. SUMMARY: Despite a lack of literature on long-term follow-up of fertility after BMT in large populations, it is clear that the risk of ovarian damage and POF is very high. Fertility preservation options should therefore be discussed with all patients having to undergo BMT.
Authors: Roman Crazzolara; Gabriele Kropshofer; Oskar A Haas; Susanne Matthes-Martin; Leo Kager Journal: Haematologica Date: 2016-12-07 Impact factor: 9.941
Authors: S Joshi; B N Savani; E J Chow; M H Gilleece; J Halter; D A Jacobsohn; J Pidala; G P Quinn; J-Y Cahn; A A Jakubowski; N R Kamani; H M Lazarus; J D Rizzo; H C Schouten; G Socie; P Stratton; M L Sorror; A B Warwick; J R Wingard; A W Loren; N S Majhail Journal: Bone Marrow Transplant Date: 2014-01-13 Impact factor: 5.483
Authors: E Biasin; F Salvagno; M Berger; F Nesi; P Quarello; E Vassallo; F Evangelista; G L Marchino; A Revelli; C Benedetto; F Fagioli Journal: Bone Marrow Transplant Date: 2015-05-11 Impact factor: 5.483