Literature DB >> 22510840

Changing the epidemiology of carbapenem-resistant Pseudomonas aeruginosa in a Brazilian teaching hospital: the replacement of São Paulo metallo-β-lactamase-producing isolates.

Felipe Lira de Sá Cavalcanti1, Anna Carolina Soares Almeida, Marinalda Anselmo Vilela, Marcia Maria Camargo de Morais, Marcos Antonio de Morais Junior.   

Abstract

In Brazil, carbapenem-resistant Pseudomonas aeruginosa isolates are closely related to the São Paulo metallo-β-lactamase (SPM) Brazilian clone. In this study, imipenem-resistant isolates were divided in two sets, 2002/2003 and 2008/2009, analysed by pulsed field gel electrophoresis and tested for the Ambler class B metallo-β-lactamase (MBL) genes blaSPM-1, blaIMP and blaVIM. The results show a prevalence of one clone related to the SPM Brazilian clone in 2002/2003. In 2008/2009, P. aeruginosa isolates were mostly MBL negative, genetically diverse and unrelated to those that had been detected earlier. These findings suggest that the resistance to carbapenems by these recent P. aeruginosa isolates was not due to the spread of MBL-positive SPM-related clones, as often observed in Brazilian hospitals.

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Year:  2012        PMID： 22510840     DOI： 10.1590/s0074-02762012000300019

Source DB:  PubMed          Journal:  Mem Inst Oswaldo Cruz        ISSN： 0074-0276            Impact factor:   2.743


  6 in total

1.  Molecular characterization and antibiogram of the carbapenemase gene variants in clinical strains of Pseudomonas aeruginosa.

Authors:  Hasan Ejaz
Journal:  Mol Biol Rep       Date:  2022-09-21       Impact factor: 2.742

2.  Surveillance and correlation of antimicrobial usage and resistance of Pseudomonas aeruginosa: a hospital population-based study.

Authors:  Jiancheng Xu; Xiumei Duan; Hui Wu; Qi Zhou
Journal:  PLoS One       Date:  2013-11-08       Impact factor: 3.240

3.  Increasing carbapenem-resistant Gram-negative bacilli and decreasing metallo-β-lactamase producers over eight years from Korea.

Authors:  Yangsoon Lee; Chang-Ki Kim; Hae-Sun Chung; Dongeun Yong; Seok Hoon Jeong; Kyungwon Lee; Yunsop Chong
Journal:  Yonsei Med J       Date:  2015-03       Impact factor: 2.759

4.  Carbapenem-resistant Pseudomonas aeruginosa: association with virulence genes and biofilm formation.

Authors:  Iara Rossi Gonçalves; Raquel Cristina Cavalcanti Dantas; Melina Lorraine Ferreira; Deivid William da Fonseca Batistão; Paulo Pinto Gontijo-Filho; Rosineide Marques Ribas
Journal:  Braz J Microbiol       Date:  2016-11-26       Impact factor: 2.476

5.  Mutational and acquired carbapenem resistance mechanisms in multidrug resistant Pseudomonas aeruginosa clinical isolates from Recife, Brazil.

Authors:  Felipe Lira de Sá Cavalcanti; Cristina Rodríguez Mirones; Elena Román Paucar; Laura Álvarez Montes; Tereza Cristina Leal-Balbino; Marcia Maria Camargo de Morais; Luis Martínez-Martínez; Alain Antonio Ocampo-Sosa
Journal:  Mem Inst Oswaldo Cruz       Date:  2015-12-15       Impact factor: 2.743

6.  Biofilm production by clinical isolates of Pseudomonas aeruginosa and structural changes in LasR protein of isolates non biofilm-producing.

Authors:  Jailton Lobo da Costa Lima; Lilian Rodrigues Alves; Paula Regina Luna de Araújo Jacomé; João Pacífico Bezerra Neto; Maria Amélia Vieira Maciel; Marcia Maria Camargo de Morais
Journal:  Braz J Infect Dis       Date:  2018-03-28       Impact factor: 3.257
  6 in total

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