OBJECTIVE: To evaluate the incidence and risk factors for grade 3 or 4 ALT or AST elevations (TE) and grade 4 total bilirubin elevations (TBE) among HIV/HCV- coinfected treatment-naïve patients with an initial regimen including 2 nucleoside analogs plus efavirenz (EFV), nevirapine (NVP), or a ritonavir-boosted protease inhibitor (PI/r). PATIENTS AND METHODS: This was a retrospective multicenter observational cohort study that recruited 745 HIV-infected drug-naïve patients with detectable plasma HCV RNA who started a regimen including EFV, NVP, or PI/r. RESULTS: EFV was prescribed in 323 (43%), NVP in 126 (17%), and a PI/r in 296 (40%) patients. Grade 3 or 4 TE were observed in 19 (5.9%) individuals receiving EFV compared with 14 (11%) on NVP (P = .056) and 31 (10.5%) on PI/r (P = .036). Grade 4 TBE were identified in 7 (2.2%) patients on EFV, 1 (0.8%) on NVP, and 11 (3.7%) on PI/r (P = .19). Therapy was discontinued due to liver toxicity in 13 (4%) patients on EFV, 16 (13%) on NVP, and 17 (6%) on PI/r (P = .003). CONCLUSIONS: Regimens including EFV, NVP, or PI/r are generally safe in treatment-naïve HIV/HCV-coinfected patients. Grade 3-4 TE are less commonly seen with EFV than with PI/r. Discontinuations due to hepatotoxicity were less frequent for patients receiving EFV than for those treated with NVP.
OBJECTIVE: To evaluate the incidence and risk factors for grade 3 or 4 ALT or AST elevations (TE) and grade 4 total bilirubin elevations (TBE) among HIV/HCV- coinfected treatment-naïve patients with an initial regimen including 2 nucleoside analogs plus efavirenz (EFV), nevirapine (NVP), or a ritonavir-boosted protease inhibitor (PI/r). PATIENTS AND METHODS: This was a retrospective multicenter observational cohort study that recruited 745 HIV-infected drug-naïve patients with detectable plasma HCV RNA who started a regimen including EFV, NVP, or PI/r. RESULTS:EFV was prescribed in 323 (43%), NVP in 126 (17%), and a PI/r in 296 (40%) patients. Grade 3 or 4 TE were observed in 19 (5.9%) individuals receiving EFV compared with 14 (11%) on NVP (P = .056) and 31 (10.5%) on PI/r (P = .036). Grade 4 TBE were identified in 7 (2.2%) patients on EFV, 1 (0.8%) on NVP, and 11 (3.7%) on PI/r (P = .19). Therapy was discontinued due to liver toxicity in 13 (4%) patients on EFV, 16 (13%) on NVP, and 17 (6%) on PI/r (P = .003). CONCLUSIONS: Regimens including EFV, NVP, or PI/r are generally safe in treatment-naïve HIV/HCV-coinfectedpatients. Grade 3-4 TE are less commonly seen with EFV than with PI/r. Discontinuations due to hepatotoxicity were less frequent for patients receiving EFV than for those treated with NVP.
Authors: Babafemi Taiwo; Elizabeth L Yanik; Sonia Napravnik; Patrick Ryscavage; Susan L Koletar; Richard Moore; W Christopher Mathews; Heidi M Crane; Kenneth Mayer; Anne Zinski; James S Kahn; Joseph J Eron Journal: AIDS Date: 2013-06-19 Impact factor: 4.177
Authors: Stefanos Kalomoiris; Je'tai Lawson; Rachel X Chen; Gerhard Bauer; Jan A Nolta; Joseph S Anderson Journal: Hum Gene Ther Methods Date: 2013-01-11 Impact factor: 2.396
Authors: Usama Bilal; Bryan Lau; Mariana Lazo; Mary E McCaul; Heidi E Hutton; Mark S Sulkowski; Richard D Moore; Geetanjali Chander Journal: AIDS Patient Care STDS Date: 2016-05 Impact factor: 5.078
Authors: Karin Neukam; Nuria Espinosa; Antonio Collado; Marcial Delgado-Fernández; Patricia Jiménez-Aguilar; Antonio Rivero-Juárez; Victor Hontañón-Antoñana; Ana Gómez-Berrocal; Josefa Ruiz-Morales; Dolores Merino; Ana Carrero; Francisco Téllez; María José Ríos; José Hernández-Quero; María de Lagarde-Sebastián; Inés Pérez-Camacho; Francisco Vera-Méndez; Juan Macías; Juan A Pineda Journal: PLoS One Date: 2016-05-19 Impact factor: 3.240
Authors: Karin Neukam; José A Mira; Antonio Collado; Antonio Rivero-Juárez; Patricia Monje-Agudo; Josefa Ruiz-Morales; María José Ríos; Dolores Merino; Francisco Téllez; Inés Pérez-Camacho; María Carmen Gálvez-Contreras; Antonio Rivero; Juan A Pineda Journal: PLoS One Date: 2016-02-05 Impact factor: 3.240