AIMS: The study aims to identify markers of vulnerability to obsessive-compulsive disorder (OCD) in an ultra-high risk sample of patients who developed psychosis. METHODS: Three hundred and eleven patients at ultra-high risk for psychosis were examined at baseline and after a mean of 7.4 years follow-up. Patients who developed psychosis with OCD (PSY + OCD; n = 13) and psychosis without OCD (PSY - OCD; n = 45) were compared in terms of socio-demographic and clinical features. RESULTS: PSY + OCD patients displayed greater severity of depression before and after conversion to PSY + OCD, and increased rates of depressive disorders before exhibiting PSY + OCD. However, they only displayed greater severity of anxiety and increased rates of non-OCD anxiety disorders after psychosis. Further, PSY + OCD patients were more likely to report a positive family history for anxiety disorders than PSY - OCD. CONCLUSION: Although depression and a family history of anxiety disorder may act as vulnerability markers for OCD in psychosis, the resulting anxiety may be a correlate or a consequence of PSY + OCD.
AIMS: The study aims to identify markers of vulnerability to obsessive-compulsive disorder (OCD) in an ultra-high risk sample of patients who developed psychosis. METHODS: Three hundred and eleven patients at ultra-high risk for psychosis were examined at baseline and after a mean of 7.4 years follow-up. Patients who developed psychosis with OCD (PSY + OCD; n = 13) and psychosis without OCD (PSY - OCD; n = 45) were compared in terms of socio-demographic and clinical features. RESULTS: PSY + OCDpatients displayed greater severity of depression before and after conversion to PSY + OCD, and increased rates of depressive disorders before exhibiting PSY + OCD. However, they only displayed greater severity of anxiety and increased rates of non-OCDanxiety disorders after psychosis. Further, PSY + OCDpatients were more likely to report a positive family history for anxiety disorders than PSY - OCD. CONCLUSION: Although depression and a family history of anxiety disorder may act as vulnerability markers for OCD in psychosis, the resulting anxiety may be a correlate or a consequence of PSY + OCD.
Authors: Laina McAusland; Lisa Buchy; Kristin S Cadenhead; Tyrone D Cannon; Barbara A Cornblatt; Robert Heinssen; Thomas H McGlashan; Diana O Perkins; Larry J Seidman; Ming T Tsuang; Elaine F Walker; Scott W Woods; Carrie E Bearden; Daniel H Mathalon; Jean Addington Journal: Early Interv Psychiatry Date: 2015-10-12 Impact factor: 2.732
Authors: Hui Lin Ong; Adela-Maria Isvoranu; Frederike Schirmbeck; Philip McGuire; Lucia Valmaggia; Matthew J Kempton; Mark van der Gaag; Anita Riecher-Rössler; Rodrigo A Bressan; Neus Barrantes-Vidal; Barnaby Nelson; G Paul Amminger; Patrick McGorry; Christos Pantelis; Marie-Odile Krebs; Merete Nordentoft; Birte Glenthøj; Stephan Ruhrmann; Gabriele Sachs; Bart P F Rutten; Jim van Os; Lieuwe de Haan; Denny Borsboom Journal: Schizophr Bull Date: 2021-07-08 Impact factor: 9.306