BACKGROUND: Data on the role of endogenous sex steroids in cerebrovascular disease are sparse. Estradiol is a hormone with diverse actions on the central nervous system. Our aim was to investigate the role of circulating estradiol levels in a postmenopausal acute stroke population. METHODS: During a time-period of 2 years, we prospectively studied 302 postmenopausal female patients hospitalized for an acute stroke in two tertiary hospitals. We addressed the question whether endogenous estradiol is associated with stroke severity on admission and functional outcome 1 month after stroke, as assessed by the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS), respectively. RESULTS: Estradiol levels were significantly related to stroke severity on admission, as expressed by NIHSS, even after correcting for confounding factors in the multivariate analysis (beta 0.353, P < 0.001). Estradiol was an independent determinant of 1-month mortality and adverse functional outcome (mRS ≥ 4), [odds ratio (OR) with 95% confidence intervals (CI): 3.341 (1.617-6.902), P = 0.001 and 2.277 (1.273-4.074), P = 0.006, respectively]. CONCLUSIONS: We identified an independent association of endogenous estradiol levels with stroke severity and short-term mortality and outcome. These findings suggest challenging the role of estradiol as a neuroprotective agent.
BACKGROUND: Data on the role of endogenous sex steroids in cerebrovascular disease are sparse. Estradiol is a hormone with diverse actions on the central nervous system. Our aim was to investigate the role of circulating estradiol levels in a postmenopausal acute stroke population. METHODS: During a time-period of 2 years, we prospectively studied 302 postmenopausal female patients hospitalized for an acute stroke in two tertiary hospitals. We addressed the question whether endogenous estradiol is associated with stroke severity on admission and functional outcome 1 month after stroke, as assessed by the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS), respectively. RESULTS:Estradiol levels were significantly related to stroke severity on admission, as expressed by NIHSS, even after correcting for confounding factors in the multivariate analysis (beta 0.353, P < 0.001). Estradiol was an independent determinant of 1-month mortality and adverse functional outcome (mRS ≥ 4), [odds ratio (OR) with 95% confidence intervals (CI): 3.341 (1.617-6.902), P = 0.001 and 2.277 (1.273-4.074), P = 0.006, respectively]. CONCLUSIONS: We identified an independent association of endogenous estradiol levels with stroke severity and short-term mortality and outcome. These findings suggest challenging the role of estradiol as a neuroprotective agent.
Authors: Elizabeth A Crago; Paula R Sherwood; Catherine Bender; Jeffrey Balzer; Dianxu Ren; Samuel M Poloyac Journal: Biol Res Nurs Date: 2014-12-29 Impact factor: 2.522
Authors: Artemis Zavaliangos-Petropulu; Bethany Lo; Miranda R Donnelly; Nicolas Schweighofer; Keith Lohse; Neda Jahanshad; Giuseppe Barisano; Nerisa Banaj; Michael R Borich; Lara A Boyd; Cathrin M Buetefisch; Winston D Byblow; Jessica M Cassidy; Charalambos C Charalambous; Adriana B Conforto; Julie A DiCarlo; Adrienne N Dula; Natalia Egorova-Brumley; Mark R Etherton; Wuwei Feng; Kelene A Fercho; Fatemeh Geranmayeh; Colleen A Hanlon; Kathryn S Hayward; Brenton Hordacre; Steven A Kautz; Mohamed Salah Khlif; Hosung Kim; Amy Kuceyeski; David J Lin; Jingchun Liu; Martin Lotze; Bradley J MacIntosh; John L Margetis; Feroze B Mohamed; Fabrizio Piras; Ander Ramos-Murguialday; Kate P Revill; Pamela S Roberts; Andrew D Robertson; Heidi M Schambra; Na Jin Seo; Mark S Shiroishi; Cathy M Stinear; Surjo R Soekadar; Gianfranco Spalletta; Myriam Taga; Wai Kwong Tang; Gregory T Thielman; Daniela Vecchio; Nick S Ward; Lars T Westlye; Emilio Werden; Carolee Winstein; George F Wittenberg; Steven L Wolf; Kristin A Wong; Chunshui Yu; Amy Brodtmann; Steven C Cramer; Paul M Thompson; Sook-Lei Liew Journal: J Am Heart Assoc Date: 2022-05-16 Impact factor: 6.106