Literature DB >> 22509427

Layers of regulation in induction of mixed chimerism by anti-CD40L.

Carrie L Lucas1, Megan Sykes.   

Abstract

The pathways regulating immunological tolerance are complex and overlapping. Here, we comment on our findings that the PD-1, CTLA-4, LAG-3 and TGFβ inhibitory molecules are all involved in mediating peripheral CD8 T‑cell tolerance induced by anti-CD40L and allogeneic bone marrow transplantation in mice. These observations suggest the possibility of targeted manipulation of these pathways for induction of mixed hematopoietic chimerism for donor-specific transplantation tolerance.

Entities:  

Keywords:  CD8 T cells; anti-CD40L; bone marrow transplantation; mixed chimerism; tolerance

Mesh：

Substances：

Year:  2011        PMID： 22509427      PMCID： PMC3321881          DOI： 10.4161/chim.2.4.19053

Source DB:  PubMed          Journal:  Chimerism        ISSN： 1938-1964


  24 in total

1.  Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway.

Authors:  Fabienne Haspot; Thomas Fehr; Carrie Gibbons; Guiling Zhao; Timothy Hogan; Tasuku Honjo; Gordon J Freeman; Megan Sykes
Journal:  Blood       Date:  2008-06-24       Impact factor: 22.113

2.  Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter.

Authors:  Heather M Gibson; Carrie J Hedgcock; Barbara M Aufiero; Adam J Wilson; Mikehl S Hafner; George C Tsokos; Henry K Wong
Journal:  J Immunol       Date:  2007-09-15       Impact factor: 5.422

3.  NFATc1 regulates PD-1 expression upon T cell activation.

Authors:  Kenneth J Oestreich; Hyesuk Yoon; Rafi Ahmed; Jeremy M Boss
Journal:  J Immunol       Date:  2008-10-01       Impact factor: 5.422

4.  LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L.

Authors:  Carrie L Lucas; Creg J Workman; Semir Beyaz; Samuel LoCascio; Guiling Zhao; Dario A A Vignali; Megan Sykes
Journal:  Blood       Date:  2011-03-21       Impact factor: 22.113

5.  CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.

Authors:  Josef Kurtz; Forum Raval; Casey Vallot; Jayden Der; Megan Sykes
Journal:  Blood       Date:  2009-01-29       Impact factor: 22.113

6.  Alloreactive CD8 T cell tolerance requires recipient B cells, dendritic cells, and MHC class II.

Authors:  Thomas Fehr; Fabienne Haspot; Joshua Mollov; Meredith Chittenden; Timothy Hogan; Megan Sykes
Journal:  J Immunol       Date:  2008-07-01       Impact factor: 5.422

7.  A novel pseudovirus containing lewis X oligosaccharides with pD-L1 targeting to DCs induces T cells tolerance.

Authors:  Xingsheng Wang; Xuemei Yang; Shehuai Cui; Yiqun Yan; Zhao Yang
Journal:  Transplantation       Date:  2009-05-15       Impact factor: 4.939

Review 8.  Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism.

Authors:  Carrie Gibbons; Megan Sykes
Journal:  Immunol Rev       Date:  2008-06       Impact factor: 12.988

9.  Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice.

Authors:  Christophe M Filippi; Elizabeth A Estes; Janine E Oldham; Matthias G von Herrath
Journal:  J Clin Invest       Date:  2009-05-26       Impact factor: 14.808

10.  Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

Authors:  Shawn D Blackburn; Haina Shin; W Nicholas Haining; Tao Zou; Creg J Workman; Antonio Polley; Michael R Betts; Gordon J Freeman; Dario A A Vignali; E John Wherry
Journal:  Nat Immunol       Date:  2008-11-30       Impact factor: 25.606
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  1 in total

Review 1.  Transplantation tolerance and its outcome during infections and inflammation.

Authors:  Anita S Chong; Maria-Luisa Alegre
Journal:  Immunol Rev       Date:  2014-03       Impact factor: 12.988
  1 in total

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