CONTEXT: Anti-Müllerian hormone (AMH) is a gonad-specific hormone, which is extensively used as a marker of gonadal status. The level of serum AMH has a high variance in similar individuals for reasons that are unknown. The AMH gene promoter contains a vitamin D response element that may cause vitamin D status to influence serum AMH levels. AIM: The objective of the study was to determine whether serum levels of AMH are related to 25-hydroxyitamin D [25(OH)D)] status. SETTING: This was a correlative and intervention study. PARTICIPANTS: Three cohorts of participants were analyzed; mature men (n = 113), premenopausal women (n = 33), and 5- to 6-yr-old boys (n = 74). Women were given a daily supplement of ergocalciferol, cholecalciferol, or a placebo for 6 months and provided baseline and posttreatment blood samples. MAIN OUTCOME MEASURES: Serum AMH and 25(OH)D were measured and analyzed for covariation. RESULTS: Serum AMH positively correlated with 25(OH)D in men (r = 0.22, P = 0.02) but not boys. Both 25(OH)D and AMH levels exhibited seasonal variation in women, with an 18% decrease in AMH levels in winter compared with summer (P = 0.01). Change in AMH level correlated with the initial AMH level and the magnitude of change in vitamin D levels (r = 0.36, P = 0.004). Cholecalciferol supplementation prevented seasonal AMH change. CONCLUSION: Vitamin D may be a positive regulator of AMH production in adults, and vitamin D deficiency may confound clinical decisions based on AMH. Vitamin D deficiency should be considered when serum AMH levels are obtained for diagnosis.
CONTEXT: Anti-Müllerian hormone (AMH) is a gonad-specific hormone, which is extensively used as a marker of gonadal status. The level of serum AMH has a high variance in similar individuals for reasons that are unknown. The AMH gene promoter contains a vitamin D response element that may cause vitamin D status to influence serum AMH levels. AIM: The objective of the study was to determine whether serum levels of AMH are related to 25-hydroxyitamin D [25(OH)D)] status. SETTING: This was a correlative and intervention study. PARTICIPANTS: Three cohorts of participants were analyzed; mature men (n = 113), premenopausal women (n = 33), and 5- to 6-yr-old boys (n = 74). Women were given a daily supplement of ergocalciferol, cholecalciferol, or a placebo for 6 months and provided baseline and posttreatment blood samples. MAIN OUTCOME MEASURES: Serum AMH and 25(OH)D were measured and analyzed for covariation. RESULTS: Serum AMH positively correlated with 25(OH)D in men (r = 0.22, P = 0.02) but not boys. Both 25(OH)D and AMH levels exhibited seasonal variation in women, with an 18% decrease in AMH levels in winter compared with summer (P = 0.01). Change in AMH level correlated with the initial AMH level and the magnitude of change in vitamin D levels (r = 0.36, P = 0.004). Cholecalciferol supplementation prevented seasonal AMH change. CONCLUSION:Vitamin D may be a positive regulator of AMH production in adults, and vitamin D deficiency may confound clinical decisions based on AMH. Vitamin D deficiency should be considered when serum AMH levels are obtained for diagnosis.
Authors: Ana B Maldonado-Cárceles; Lidia Mínguez-Alarcón; Irene Souter; Audrey J Gaskins; Mariel Arvizu; Paige L Williams; Jennifer B Ford; Jorge E Chavarro Journal: Fertil Steril Date: 2020-07-22 Impact factor: 7.329
Authors: Alexandra C Purdue-Smithe; Brian W Whitcomb; Kathleen L Szegda; Maegan E Boutot; JoAnn E Manson; Susan E Hankinson; Bernard A Rosner; Lisa M Troy; Karin B Michels; Elizabeth R Bertone-Johnson Journal: Am J Clin Nutr Date: 2017-05-10 Impact factor: 7.045