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Literature DB >> 22508266

Will the real aging Sirtuin please stand up?

Abstract

Initial studies linking Sirtuins to longevity in yeast initiated what is now a rich vein of aging research that is full of promise and fraught with controversy. Missing was a demonstration that enhanced Sirtuin expression extends lifespan in mammals. Now Kanfi et al. provide the evidence but with an interesting plot twist - the lesser known SIRT6 is the longevity factor.

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Year: 2012 PMID： 22508266 PMCID： PMC3411170 DOI： 10.1038/cr.2012.62

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

16 in total

1. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Authors: Raul Mostoslavsky; Katrin F Chua; David B Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael O Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Journal: Cell Date: 2006-01-27 Impact factor: 41.582

Review 2. Sirtuins, aging, and metabolism.

Authors: Leonard Guarente
Journal: Cold Spring Harb Symp Quant Biol Date: 2011-11-23

3. p53 mutant mice that display early ageing-associated phenotypes.

Authors: Stuart D Tyner; Sundaresan Venkatachalam; Jene Choi; Stephen Jones; Nader Ghebranious; Herbert Igelmann; Xiongbin Lu; Gabrielle Soron; Benjamin Cooper; Cory Brayton; Sang Hee Park; Timothy Thompson; Gerard Karsenty; Allan Bradley; Lawrence A Donehower
Journal: Nature Date: 2002-01-03 Impact factor: 49.962

4. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors: M Kaeberlein; M McVey; L Guarente
Journal: Genes Dev Date: 1999-10-01 Impact factor: 11.361

5. The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability.

Authors: Bo Yang; Bernadette M M Zwaans; Mark Eckersdorff; David B Lombard
Journal: Cell Cycle Date: 2009-08-22 Impact factor: 4.534

6. Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

Authors: Eriko Michishita; Ronald A McCord; Lisa D Boxer; Matthew F Barber; Tao Hong; Or Gozani; Katrin F Chua
Journal: Cell Cycle Date: 2009-08-26 Impact factor: 4.534

7. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.

Authors: Eriko Michishita; Ronald A McCord; Elisabeth Berber; Mitomu Kioi; Hesed Padilla-Nash; Mara Damian; Peggie Cheung; Rika Kusumoto; Tiara L A Kawahara; J Carl Barrett; Howard Y Chang; Vilhelm A Bohr; Thomas Ried; Or Gozani; Katrin F Chua
Journal: Nature Date: 2008-03-12 Impact factor: 49.962

8. SIRT6 protects against pathological damage caused by diet-induced obesity.

Authors: Yariv Kanfi; Victoria Peshti; Reuven Gil; Shoshana Naiman; Liat Nahum; Eran Levin; Noga Kronfeld-Schor; Haim Y Cohen
Journal: Aging Cell Date: 2009-12-28 Impact factor: 9.304

Review 9. 'Accelerated aging': a primrose path to insight?

Authors: Richard A Miller
Journal: Aging Cell Date: 2004-04 Impact factor: 9.304

10. Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse.

Authors: William R Swindell
Journal: BMC Genomics Date: 2009-12-07 Impact factor: 3.969

5 in total

1. SIRT6, oxidative stress, and aging.

Authors: Chen-Yu Liao; Brian K Kennedy
Journal: Cell Res Date: 2016-01-19 Impact factor: 25.617

2. The transcriptional repressor Sum1p counteracts Sir2p in regulation of the actin cytoskeleton, mitochondrial quality control and replicative lifespan in Saccharomyces cerevisiae.

Authors: Ryo Higuchi-Sanabria; Jason D Vevea; Joseph K Charalel; Maria L Sapar; Liza A Pon
Journal: Microb Cell Date: 2016-01-18

Review 3. SIRT6 in Senescence and Aging-Related Cardiovascular Diseases.

Authors: Xiaokang Li; Lin Liu; Tian Li; Manling Liu; Yishi Wang; Heng Ma; Nan Mu; Haiyan Wang
Journal: Front Cell Dev Biol Date: 2021-03-29

Review 4. Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes.

Authors: Albert E Berman; Olga V Leontieva; Venkatesh Natarajan; James A McCubrey; Zoya N Demidenko; Mikhail A Nikiforov
Journal: Oncotarget Date: 2012-12

5. A multi-platform draft de novo genome assembly and comparative analysis for the Scarlet Macaw (Ara macao).

Authors: Christopher M Seabury; Scot E Dowd; Paul M Seabury; Terje Raudsepp; Donald J Brightsmith; Poul Liboriussen; Yvette Halley; Colleen A Fisher; Elaine Owens; Ganesh Viswanathan; Ian R Tizard
Journal: PLoS One Date: 2013-05-08 Impact factor: 3.240

5 in total