Min Wang1, Yuan Zhang, Demin Han, Luo Zhang. 1. Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, PR China.
Abstract
BACKGROUND: Th17 cell lineage, a distinct pro-inflammatory lineage characterized by preferential synthesis of cytokines IL-17A and IL-17F, is thought to play an important role in the pathogenesis of allergic rhinitis (AR). OBJECTIVES: Our aim was to investigate whether polymorphisms in and around IL-17A and IL-17F genes are associated with AR and comorbid asthma. METHODS: A case-control comparison was performed in a cohort of 279 AR patients, 197 allergic rhinitis with asthma (AR-A) patients and 281 control Chinese subjects, to investigate associations between 19 tagging single-nucleotide polymorphisms (SNPs) in IL-17A and IL-17F gene regions and manifestation of AR or AR-A. Genotyping was performed using the Sequenom MassARRAY platform. RESULTS: SNP rs3819024 in IL-17A gene, intergenic SNPs rs1892280 and rs10807439 were specifically associated with AR protective or risk effects, while rs3819024 in IL-17A gene, intergenic SNP rs13192563 in IL-17F gene were associated with AR-A protective or risk effects. Haplotype analysis showed significant AR risk in haplotype AA (rs1892280G-rs13192563A) and AR protective effect in haplotype GT (rs7758579A-rs11966760T); the haplotype AT(rs7758579-rs11966760) were considered AR-A risk. CONCLUSIONS: Our findings preliminarily indicate IL17A and IL17F SNPs, and some intergenic variants have the potential association with AR and comorbid asthma in Chinese population.
BACKGROUND: Th17 cell lineage, a distinct pro-inflammatory lineage characterized by preferential synthesis of cytokines IL-17A and IL-17F, is thought to play an important role in the pathogenesis of allergic rhinitis (AR). OBJECTIVES: Our aim was to investigate whether polymorphisms in and around IL-17A and IL-17F genes are associated with AR and comorbid asthma. METHODS: A case-control comparison was performed in a cohort of 279 AR patients, 197 allergic rhinitis with asthma (AR-A) patients and 281 control Chinese subjects, to investigate associations between 19 tagging single-nucleotide polymorphisms (SNPs) in IL-17A and IL-17F gene regions and manifestation of AR or AR-A. Genotyping was performed using the Sequenom MassARRAY platform. RESULTS: SNP rs3819024 in IL-17A gene, intergenic SNPs rs1892280 and rs10807439 were specifically associated with AR protective or risk effects, while rs3819024 in IL-17A gene, intergenic SNP rs13192563 in IL-17F gene were associated with AR-A protective or risk effects. Haplotype analysis showed significant AR risk in haplotype AA (rs1892280G-rs13192563A) and AR protective effect in haplotype GT (rs7758579A-rs11966760T); the haplotype AT(rs7758579-rs11966760) were considered AR-A risk. CONCLUSIONS: Our findings preliminarily indicate IL17A and IL17F SNPs, and some intergenic variants have the potential association with AR and comorbid asthma in Chinese population.
Authors: Michelle L Manni; Sivanarayana Mandalapu; Kevin J McHugh; M Merle Elloso; Paul L Dudas; John F Alcorn Journal: J Immunol Date: 2016-01-04 Impact factor: 5.422
Authors: F Fatahi; Ars Chaleshtori; K Ghatreh Samani; S M Mousavi; F Zandi; S Heydari; M Hashemzadeh Chaleshtori; M Amiri; H Khazraee Journal: Ann Med Health Sci Res Date: 2016 Jul-Aug
Authors: Milca de J Silva; Maria B R de Santana; Bruna R Tosta; Roberta P Espinheira; Neuza Maria Alcantara-Neves; Maurício L Barreto; Camila Alexandrina Figueiredo; Ryan Dos S Costa Journal: Allergy Asthma Clin Immunol Date: 2019-04-29 Impact factor: 3.406