| Literature DB >> 22507594 |
Li Di1, Per Artursson, Alex Avdeef, Gerhard F Ecker, Bernard Faller, Holger Fischer, J Brian Houston, Manfred Kansy, Edward H Kerns, Stefanie D Krämer, Hans Lennernäs, Kiyohiko Sugano.
Abstract
Evidence supporting the action of passive diffusion and carrier-mediated (CM) transport in drug bioavailability and disposition is discussed to refute the recently proposed theory that drug transport is CM-only and that new transporters will be discovered that possess transport characteristics ascribed to passive diffusion. Misconceptions and faulty speculations are addressed to provide reliable guidance on choosing appropriate tools for drug design and optimization.Mesh：
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Year: 2012 PMID： 22507594 DOI： 10.1016/j.drudis.2012.03.015
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851