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Literature DB >> 22506644

How biologics targeting the IL-1 system are being considered for the treatment of type 2 diabetes.

Marianne Böni-Schnetzler¹, Marc Y Donath.

Abstract

Metabolic diseases are associated with activation of the innate immune system in various tissues and characterized by elevated inflammatory factors and the presence of immune cells. Type 2 diabetes develops when islet beta cells are deficient in producing sufficient insulin to overcome peripheral insulin resistance. Intra-islet IL-1β activity diminishes beta cell function and survival and governs islet inflammation. Targeting the IL-1 system with the IL-1 receptor antagonist IL1Ra improved insulin secretion, glycaemia and reduced systemic inflammation in a proof of concept study with patients with type 2 diabetes. Currently, long lasting and specific IL-1β blocking antibodies are being evaluated in clinical trials and this may lead to a novel cytokine-based treatment for type 2 diabetes.

Entities: Disease Gene Species

Keywords: IL-1β; cytokines; inflammation; type 2 diabetes

Mesh：

Substances：

Year: 2013 PMID： 22506644 PMCID： PMC3731600 DOI： 10.1111/j.1365-2125.2012.04297.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

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