| Literature DB >> 22506638 |
Fabiano Pereira do Amaral1, Assunta Napolitano, Milena Masullo, Lourdes Campaner dos Santos, Michela Festa, Wagner Vilegas, Cosimo Pizza, Sonia Piacente.
Abstract
The methanol extract of the flowers of Paepalanthus geniculatus Kunth. showed radical-scavenging activity in the TEAC assay. An analytical approach based on HPLC-ESIMS(n) was applied to obtain the metabolite profile of this extract and led to the rapid identification of 19 polyphenolic compounds comprising flavonoids and naphthopyranones. The new naphthopyranone (10, 16), quercetagetin (1, 5, 7, 13), and galetine derivatives (9, 11, 17, 19), and a flavonol glucoside cyclodimer in the truxillate form (12), were identified. Compounds 2, 6, and 7 showed the highest antioxidant capacity and ability to affect the levels of intracellular ROS in human prostate cancer cells (PC3).Entities:
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Year: 2012 PMID： 22506638 DOI： 10.1021/np200604k
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050