Literature DB >> 22506484

Structural modifications that alter the P-glycoprotein efflux properties of compounds.

Stephen A Hitchcock1.   

Abstract

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Year:  2012        PMID: 22506484     DOI: 10.1021/jm201136z

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


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  33 in total

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2.  Structural and conformational determinants of macrocycle cell permeability.

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3.  Predicting efflux ratios and blood-brain barrier penetration from chemical structure: combining passive permeability with active efflux by P-glycoprotein.

Authors:  Elena Dolghih; Matthew P Jacobson
Journal:  ACS Chem Neurosci       Date:  2012-12-11       Impact factor: 4.418

4.  Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators.

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Journal:  ACS Med Chem Lett       Date:  2014-02-20       Impact factor: 4.345

Review 5.  Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.

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Journal:  J Med Chem       Date:  2015-04-01       Impact factor: 7.446

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Journal:  J Med Chem       Date:  2017-05-19       Impact factor: 7.446

8.  Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter.

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9.  A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives.

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Journal:  J Med Chem       Date:  2012-12-17       Impact factor: 7.446

10.  Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.

Authors:  John C Lukesh; Daniel W Carney; Huijun Dong; R Matthew Cross; Vyom Shukla; Katharine K Duncan; Shouliang Yang; Daniel M Brody; Manuela M Brütsch; Aleksandar Radakovic; Dale L Boger
Journal:  J Med Chem       Date:  2017-08-31       Impact factor: 7.446

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