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Literature DB >> 22505664

Electrically silent Kv subunits: their molecular and functional characteristics.

Abstract

Electrically silent voltage-gated potassium (KvS) α-subunits do not form homotetramers but heterotetramerize with Kv2 subunits, generating functional Kv2/KvS channel complexes in which the KvS subunits modulate the Kv2 current. This poses intriguing questions into the molecular mechanisms by which these KvS subunits cannot form functional homotetramers, why they only interact with Kv2 subunits, and how they modulate the Kv2 current.

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Year: 2012 PMID： 22505664 DOI： 10.1152/physiol.00023.2011

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

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Cited

35 in total

Review 1. Breaking barriers to novel analgesic drug development.

Authors: Ajay S Yekkirala; David P Roberson; Bruce P Bean; Clifford J Woolf
Journal: Nat Rev Drug Discov Date: 2017-06-09 Impact factor: 84.694

2. Ion channels and pain: important steps towards validating a new therapeutic target for neuropathic pain.

Authors: James S Trimmer
Journal: Exp Neurol Date: 2014-02-05 Impact factor: 5.330

3. Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.

Authors: Evelyn Martinez-Morales; Dirk J Snyders; Alain J Labro
Journal: Biophys J Date: 2014-01-07 Impact factor: 4.033

4. Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations.

Authors: Lena Möller; Glenn Regnier; Alain J Labro; Rikard Blunck; Dirk J Snyders
Journal: Proc Natl Acad Sci U S A Date: 2020-04-13 Impact factor: 11.205

10. Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex.

Authors: Danko Georgiev; Guillermo González-Burgos; Mitsuru Kikuchi; Yoshio Minabe; David A Lewis; Takanori Hashimoto
Journal: PLoS One Date: 2012-08-24 Impact factor: 3.240

Electrically silent Kv subunits: their molecular and functional characteristics.

Review 1. Breaking barriers to novel analgesic drug development.

2. Ion channels and pain: important steps towards validating a new therapeutic target for neuropathic pain.

3. Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.

4. Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations.

5. Heteromeric K_V2/K_V8.2 Channels Mediate Delayed Rectifier Potassium Currents in Primate Photoreceptors.

6. Functional analysis of missense mutations in Kv8.2 causing cone dystrophy with supernormal rod electroretinogram.

7. Functional Expression Profile of Voltage-Gated K(+) Channel Subunits in Rat Small Mesenteric Arteries.

8. Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties.

9. Being flexible: the voltage-controllable activation gate of kv channels.

10. Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex.