| Literature DB >> 22504020 |
Hongqiao Zhang1, Henry Jay Forman.
Abstract
Glutathione (GSH) is the most abundant antioxidant and a major detoxification agent in cells. It is synthesized through two-enzyme reaction catalyzed by glutamate cysteine ligase and glutathione synthetase, and its level is well regulated in response to redox change. Accumulating evidence suggests that GSH may play important roles in cell signaling. This review will focus on the biosynthesis of GSH, the reaction of S-glutathionylation (the conjugation of GSH with thiol residue on proteins), GSNO, and their roles in redox signaling.Entities:
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Year: 2012 PMID： 22504020 PMCID： PMC3422610 DOI： 10.1016/j.semcdb.2012.03.017
Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727