| Literature DB >> 22503821 |
Han Liu1, Xuqi Li, Qinhong Xu, Shifang Lv, Junhui Li, Qingyong Ma.
Abstract
Perineural invasion (PNI) is the initial infiltration of tumor cells into the retroperitoneal nerve plexus and along the nerves. It precludes curative resection, is thought to be the major cause of local recurrence following resection, and is a special metastatic route in pancreatic cancer. Glial cell line-derived neurotrophic factor (GDNF) was recently recognized as a key player in the PNI process. This review covers the most recently published studies on the role of GDNF in pancreatic cancer. We introduce the players in PNI, summarize the distribution of GDNF and its receptors in pancreatic cancer, and discuss the effects and underlying mechanism of GDNF in the PNI process. Finally, we also review some potential inhibitors for GDNF-targeted therapy.Entities:
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Year: 2012 PMID： 22503821 DOI： 10.1016/j.bbcan.2012.03.010
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002