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Literature DB >> 22503553

miRNAs and estrogen action.

Abstract

MicroRNAs (miRNAs) are short, noncoding RNAs that generally base-pair within the 3' untranslated region of target mRNAs causing translational inhibition and/or mRNA degradation. Estradiol (E(2)) and other estrogen receptor (ER) ligands suppress or stimulate miRNA expression in human breast cancer cells, endometrial cells, rat mammary gland, and mouse uterus, and post-translationally regulate protein expression. Aberrant miRNA expression is implicated in estrogen-related breast and endometrial cancers, and several miRNAs downregulate ERα. The role of estrogen-regulated miRNA expression, the target genes of these miRNAs, and the role of miRNAs in health and disease is a 'hot' area of research that will yield new insight into molecular mechanisms of estrogen action.

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Year: 2012 PMID： 22503553 PMCID： PMC3348384 DOI： 10.1016/j.tem.2012.03.002

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

100 in total

Review 1. Minireview: Extranuclear steroid receptors: roles in modulation of cell functions.

Authors: Ellis R Levin
Journal: Mol Endocrinol Date: 2010-09-22

Review 2. Emerging complexity of microRNA generation cascades.

Authors: Hiroshi I Suzuki; Kohei Miyazono
Journal: J Biochem Date: 2010-09-27 Impact factor: 3.387

3. Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.

Authors: Tissa T Manavalan; Yun Teng; Savitri N Appana; Susmita Datta; Theodore S Kalbfleisch; Yong Li; Carolyn M Klinge
Journal: Cancer Lett Date: 2011-09-10 Impact factor: 8.679

Review 4. Mechanisms of tamoxifen resistance.

Authors: Alistair Ring; Mitch Dowsett
Journal: Endocr Relat Cancer Date: 2004-12 Impact factor: 5.678

5. MicroRNAs link estrogen receptor alpha status and Dicer levels in breast cancer.

Authors: Dawn R Cochrane; Diana M Cittelly; Erin N Howe; Nicole S Spoelstra; Erin L McKinsey; Kelly LaPara; Anthony Elias; Douglas Yee; Jennifer K Richer
Journal: Horm Cancer Date: 2010-12 Impact factor: 3.869

6. MicroRNA-101-mediated Akt activation and estrogen-independent growth.

Authors: M Sachdeva; H Wu; P Ru; L Hwang; V Trieu; Y-Y Mo
Journal: Oncogene Date: 2010-10-18 Impact factor: 9.867

7. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.

Authors: Lisa B Frankel; Nanna R Christoffersen; Anders Jacobsen; Morten Lindow; Anders Krogh; Anders H Lund
Journal: J Biol Chem Date: 2007-11-08 Impact factor: 5.157

8. miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer.

Authors: Naoto Kondo; Tatsuya Toyama; Hiroshi Sugiura; Yoshitaka Fujii; Hiroko Yamashita
Journal: Cancer Res Date: 2008-07-01 Impact factor: 12.701

9. Identification of microRNAs controlling human ovarian cell steroidogenesis via a genome-scale screen.

Authors: Alexander V Sirotkin; Dmitriy Ovcharenko; Roland Grossmann; Marcela Lauková; Milos Mlyncek
Journal: J Cell Physiol Date: 2009-05 Impact factor: 6.384

10. MicroRNA-184 downregulates nuclear receptor corepressor 2 in mouse spermatogenesis.

Authors: Jingwen Wu; Jianqiang Bao; Li Wang; Yanqin Hu; Chen Xu
Journal: BMC Dev Biol Date: 2011-10-24 Impact factor: 1.978

73 in total

Review 1. Estrogens regulate life and death in mitochondria.

Authors: Carolyn M Klinge
Journal: J Bioenerg Biomembr Date: 2017-08 Impact factor: 2.945

2. Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression.

Authors: Julie Lorent; Eric P Kusnadi; Vincent van Hoef; Richard J Rebello; Matthew Leibovitch; Johannes Ristau; Shan Chen; Mitchell G Lawrence; Krzysztof J Szkop; Baila Samreen; Preetika Balanathan; Francesca Rapino; Pierre Close; Patricia Bukczynska; Karin Scharmann; Itsuhiro Takizawa; Gail P Risbridger; Luke A Selth; Sebastian A Leidel; Qishan Lin; Ivan Topisirovic; Ola Larsson; Luc Furic
Journal: EMBO J Date: 2019-09-26 Impact factor: 11.598

3. Regulation of transcriptional activation function of rat estrogen receptor α (ERα) by novel C-terminal splice inserts.

Authors: Pallob Kundu; Min Li; Rong Lu; Enrico Stefani; Ligia Toro
Journal: Mol Cell Endocrinol Date: 2014-11-07 Impact factor: 4.102

miRNAs and estrogen action.

Review 1. Minireview: Extranuclear steroid receptors: roles in modulation of cell functions.

Review 2. Emerging complexity of microRNA generation cascades.

3. Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.

Review 4. Mechanisms of tamoxifen resistance.

5. MicroRNAs link estrogen receptor alpha status and Dicer levels in breast cancer.

6. MicroRNA-101-mediated Akt activation and estrogen-independent growth.

7. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.

8. miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer.

9. Identification of microRNAs controlling human ovarian cell steroidogenesis via a genome-scale screen.

10. MicroRNA-184 downregulates nuclear receptor corepressor 2 in mouse spermatogenesis.

Review 1. Estrogens regulate life and death in mitochondria.

2. Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression.

3. Regulation of transcriptional activation function of rat estrogen receptor α (ERα) by novel C-terminal splice inserts.

4. Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.

5. Dehydroepiandrosterone-induces miR-21 transcription in HepG2 cells through estrogen receptor β and androgen receptor.

Review 6. The novel role of miRNAs for tamoxifen resistance in human breast cancer.

Review 7. microRNAs and the adolescent brain: Filling the knowledge gap.

8. Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.

9. Plasma microRNAs in ovarian cancer--response.

Review 10. Epigenetic mechanisms in pubertal brain maturation.