STUDY OBJECTIVE: In 2005, the International Committee of Medical Journal Editors established clinical trial registration as a requirement for articles submitted to member journals, with the goal of improving the transparency of clinical research. The objective of this study is to characterize the registration of clinical trials published in emergency medicine journals. METHODS: Randomized trials involving human subjects and published between June 1, 2008, and May 31, 2011 in the 5 emergency medicine journals with the highest impact factors were included. We assessed the clarity of registered primary outcomes, timing of registration relative to patient enrollment, and consistency between registered and published outcomes. RESULTS: Of the 123 trials included, registry entries were identified for 57 (46%). Of the 57 registered studies, 45 (79%) were registered after the initiation of subject enrollment, 9 (16%) had registered outcomes that were unclear, and 26 (46%) had discrepancies between registered and published outcomes. Only 5 studies were registered before patient enrollment with a clear primary outcome that was consistent with the published primary outcome. Annals of Emergency Medicine was the only journal in which the majority of trials were registered. CONCLUSION: Current compliance with clinical trial registration guidelines is poor among trials published in emergency medicine journals.
STUDY OBJECTIVE: In 2005, the International Committee of Medical Journal Editors established clinical trial registration as a requirement for articles submitted to member journals, with the goal of improving the transparency of clinical research. The objective of this study is to characterize the registration of clinical trials published in emergency medicine journals. METHODS: Randomized trials involving human subjects and published between June 1, 2008, and May 31, 2011 in the 5 emergency medicine journals with the highest impact factors were included. We assessed the clarity of registered primary outcomes, timing of registration relative to patient enrollment, and consistency between registered and published outcomes. RESULTS: Of the 123 trials included, registry entries were identified for 57 (46%). Of the 57 registered studies, 45 (79%) were registered after the initiation of subject enrollment, 9 (16%) had registered outcomes that were unclear, and 26 (46%) had discrepancies between registered and published outcomes. Only 5 studies were registered before patient enrollment with a clear primary outcome that was consistent with the published primary outcome. Annals of Emergency Medicine was the only journal in which the majority of trials were registered. CONCLUSION: Current compliance with clinical trial registration guidelines is poor among trials published in emergency medicine journals.
Authors: Matthew Thomas Sims; Zachary Carter Sanchez; James Murphy Herrington; James Barrett Hensel; Nolan Michael Henning; Caleb Josiah Scheckel; Matt Vassar Journal: PLoS One Date: 2016-10-20 Impact factor: 3.240
Authors: Anand D Gopal; Joshua D Wallach; Jenerius A Aminawung; Gregg Gonsalves; Rafael Dal-Ré; Jennifer E Miller; Joseph S Ross Journal: Trials Date: 2018-08-23 Impact factor: 2.279
Authors: Christopher W Jones; Lukas G Keil; Wesley C Holland; Melissa C Caughey; Timothy F Platts-Mills Journal: BMC Med Date: 2015-11-18 Impact factor: 8.775
Authors: Benjamin Howard; Jared T Scott; Mark Blubaugh; Brie Roepke; Caleb Scheckel; Matt Vassar Journal: PLoS One Date: 2017-07-20 Impact factor: 3.240