| Literature DB >> 22503247 |
Andrew R Germain1, Leigh C Carmody, Barbara Morgan, Cristina Fernandez, Erin Forbeck, Timothy A Lewis, Partha P Nag, Amal Ting, Lynn VerPlank, Yuxiong Feng, Jose R Perez, Sivaraman Dandapani, Michelle Palmer, Eric S Lander, Piyush B Gupta, Stuart L Schreiber, Benito Munoz.
Abstract
A high-throughput screen (HTS) with the National Institute of Health-Molecular Libraries Small Molecule Repository (NIH-MLSMR) compound collection identified a class of acyl hydrazones to be selectively lethal to breast cancer stem cell (CSC) enriched populations. Medicinal chemistry efforts were undertaken to optimize potency and selectivity of this class of compounds. The optimized compound was declared as a probe (ML239) with the NIH Molecular Libraries Program and displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control line (HMLE_sh_GFP).Entities:
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Year: 2012 PMID： 22503247 DOI： 10.1016/j.bmcl.2012.01.035
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823