Literature DB >> 22503246

Long-acting peptidomimetics based DPP-IV inhibitors.

Pradip Jadav1, Rajesh Bahekar, Shailesh R Shah, Dipam Patel, Amit Joharapurkar, Samadhan Kshirsagar, Mukul Jain, Mubeen Shaikh, Kalapatapu V V M Sairam.   

Abstract

Pyrrolidine based peptidomimetics are reported as potent and selective DPP-IV inhibitors for the treatment of T2DM. Compounds 16c and 16d showed excellent in vitro potency and selectivity towards DPP-IV and the lead compound 16c showed sustained antihyperglycemic effects, along with improved pharmacokinetic profile.
Copyright © 2012 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22503246     DOI： 10.1016/j.bmcl.2012.03.078

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Molecular dynamic simulations reveal the mechanism of binding between xanthine inhibitors and DPP-4.

Authors:  Yongliang Gu; Wei Wang; Xiaolei Zhu; Keke Dong
Journal:  J Mol Model       Date:  2014-01-31       Impact factor: 1.810

2.  Antioxidant and Antidiabetic Effects of Flavonoids: A Structure-Activity Relationship Based Study.

Authors:  Murni Nazira Sarian; Qamar Uddin Ahmed; Siti Zaiton Mat So'ad; Alhassan Muhammad Alhassan; Suganya Murugesu; Vikneswari Perumal; Sharifah Nurul Akilah Syed Mohamad; Alfi Khatib; Jalifah Latip
Journal:  Biomed Res Int       Date:  2017-11-28       Impact factor: 3.411

3.  Protease Inhibitors Purified from the Canola Meal Extracts of Two Genetically Diverse Genotypes Exhibit Antidiabetic and Antihypertension Properties.

Authors:  Saira Hussain; Ata Ur Rehman; David J Luckett; Syed Muhammad Saqlan Naqvi; Christopher L Blanchard
Journal:  Molecules       Date:  2021-04-04       Impact factor: 4.411

4.  Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats.

Authors:  Prawej Ansari; Mary P Hannon-Fletcher; Peter R Flatt; Yasser H A Abdel-Wahab
Journal:  Biosci Rep       Date:  2021-01-29       Impact factor: 3.840

5.  Expanding the chemical space of 3(5)-functionalized 1,2,4-triazoles.

Authors:  Dmytro M Khomenko; Roman O Doroshchuk; Yulia M Ohorodnik; Hanna V Ivanova; Borys V Zakharchenko; Ilona V Raspertova; Oleksandr V Vaschenko; Alexey V Dobrydnev; Oleksandr O Grygorenko; Rostyslav D Lampeka
Journal:  Chem Heterocycl Compd (N Y)       Date:  2022-03-23       Impact factor: 1.490

Review 6.  Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes.

Authors:  Anand-Krishna Singh; Dhananjay Yadav; Neha Sharma; Jun-O Jin
Journal:  Pharmaceuticals (Basel)       Date:  2021-06-18

7.  Berry Phenolic Compounds Increase Expression of Hepatocyte Nuclear Factor-1α (HNF-1α) in Caco-2 and Normal Colon Cells Due to High Affinities with Transcription and Dimerization Domains of HNF-1α.

Authors:  Luis M Real Hernandez; Junfeng Fan; Michelle H Johnson; Elvira Gonzalez de Mejia
Journal:  PLoS One       Date:  2015-09-28       Impact factor: 3.240

8.  Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV: Implications in Diabetes Management.

Authors:  Junfeng Fan; Michelle H Johnson; Mary Ann Lila; Gad Yousef; Elvira Gonzalez de Mejia
Journal:  Evid Based Complement Alternat Med       Date:  2013-08-29       Impact factor: 2.629
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.