Literature DB >> 22500543

Pharmacokinetics and pharmacodynamic changes associated with aging and implications for drug therapy.

Leah Church Sera1, Mary Lynn McPherson.   

Abstract

The population of older adults continues to increase, and polypharmacy in this population is more the rule than the exception. Physiologic changes that occur with aging result in multiple alterations to the pharmacokinetics and pharmacodynamics of drugs, which, in turn, increase the risk of adverse drug reactions. Consideration of initial dose adjustment, along with frequent medication reconciliation and analysis of the medication list, are keys to providing optimal pharmaceutical care for elderly patients.

Entities:  

Mesh：

Year:  2012        PMID： 22500543     DOI： 10.1016/j.cger.2012.01.007

Source DB:  PubMed          Journal:  Clin Geriatr Med        ISSN： 0749-0690            Impact factor:   3.076


  32 in total

1.  Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop.

Authors:  Janice B Schwartz; Kenneth E Schmader; Joseph T Hanlon; Darrell R Abernethy; Shelly Gray; Jacqueline Dunbar-Jacob; Holly M Holmes; Michael D Murray; Robert Roberts; Michael Joyner; Josh Peterson; David Lindeman; Ming Tai-Seale; Laura Downey; Michael W Rich
Journal:  J Am Geriatr Soc       Date:  2018-12-07       Impact factor: 5.562

2.  Use of benzodiazepines and association with falls in older people admitted to hospital: a prospective cohort study.

Authors:  Anna Ballokova; Nancye M Peel; Daniela Fialova; Ian A Scott; Leonard C Gray; Ruth E Hubbard
Journal:  Drugs Aging       Date:  2014-04       Impact factor: 3.923

3.  Impact of multiple low-level anticholinergic medications on anticholinergic load of community-dwelling elderly with and without dementia.

Authors:  Karen E Mate; Karen P Kerr; Dimity Pond; Evan J Williams; John Marley; Peter Disler; Henry Brodaty; Parker J Magin
Journal:  Drugs Aging       Date:  2015-02       Impact factor: 3.923

4.  Rural-Urban Differences in Chronic Disease and Drug Utilization in Older Oregonians.

Authors:  Leah M Goeres; Allison Gille; Jon P Furuno; Deniz Erten-Lyons; Daniel M Hartung; James F Calvert; Sharia M Ahmed; David S H Lee
Journal:  J Rural Health       Date:  2015-10-30       Impact factor: 4.333

5.  Prevalence and Factors Associated with Analgesic Prescribing in Poly-Medicated Elderly Patients.

Authors:  Aymen Ali Al-Qurain; Lemlem G Gebremichael; Muhammad Suleman Khan; Desmond B Williams; Lorraine Mackenzie; Craig Phillips; Patrick Russell; Michael S Roberts; Michael D Wiese
Journal:  Drugs Aging       Date:  2020-04       Impact factor: 3.923

6.  Health care professionals' attitudes towards deprescribing in older patients with limited life expectancy: A systematic review.

Authors:  Carina Lundby; Trine Graabaek; Jesper Ryg; Jens Søndergaard; Anton Pottegård; Dorthe Susanne Nielsen
Journal:  Br J Clin Pharmacol       Date:  2019-02-27       Impact factor: 4.335

7.  Incidence and Predictors of Aspirin Discontinuation in Older Adult Veteran Nursing Home Residents at End of Life.

Authors:  Sydney P Springer; Maria K Mor; Florentina Sileanu; Xinhua Zhao; Sherrie L Aspinall; Mary Ersek; Joshua D Niznik; Joseph T Hanlon; Jacob Hunnicutt; Walid F Gellad; Loren J Schleiden; Joshua M Thorpe; Carolyn T Thorpe
Journal:  J Am Geriatr Soc       Date:  2020-02-13       Impact factor: 5.562

8.  The Relationship Between Polypharmacy and Hospital-stay Duration: A Retrospective Study.

Authors:  Nobuhiko Fukuba; Mutsuko Nishida; Miki Hayashi; Natsuko Furukawa; Hitomi Ishitobi; Makoto Nagaoka; Yoshiko Takahashi; Hiroyuki Fukuhara; Mika Yuki; Yoshinori Komazawa; Shuichi Sato; Toshihiro Shizuku
Journal:  Cureus       Date:  2020-03-14

Review 9.  The economic burden of inappropriate drug prescribing, lack of adherence and compliance, adverse drug events in older people: a systematic review.

Authors:  Carlos Chiatti; Silvia Bustacchini; Gianluca Furneri; Lorenzo Mantovani; Marco Cristiani; Clementina Misuraca; Fabrizia Lattanzio
Journal:  Drug Saf       Date:  2012-01       Impact factor: 5.606

Review 10.  Adverse drug events as a cause of hospitalization in older adults.

Authors:  Fabio Salvi; Annalisa Marchetti; Federica D'Angelo; Massimo Boemi; Fabrizia Lattanzio; Antonio Cherubini
Journal:  Drug Saf       Date:  2012-01       Impact factor: 5.606
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.