Literature DB >> 22500050

ALDH marks leukemia stem cell.

Angela G Fleischman1.   

Abstract

In this issue of Blood,Gerber et al use aldehyde dehydrogenase (ALDH) activity to further subdivide the CD34(+)CD38(-) compartment in the bone marrow of acute myeloid leukemia (AML) patients. They identify a unique population with intermediate ALDH activity (ALDH(int)) that contains leukemia stem cells (LSCs). Moreover, persistence of this population after therapy is a marker of clinically significant minimal residual disease.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22500050     DOI： 10.1182/blood-2012-02-406751

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  13 in total

1.  N,N-diethylaminobenzaldehyde targets aldehyde dehydrogenase to eradicate human pancreatic cancer cells.

Authors:  Wenwen Wang; Shiya Zheng; Haiju He; Hao Ge; Borhan R Saeed
Journal:  Exp Ther Med       Date:  2020-04-27       Impact factor: 2.447

Review 2.  Mitochondrial membrane potential and reactive oxygen species in cancer stem cells.

Authors:  Bei-bei Zhang; Dao-gang Wang; Fen-fen Guo; Chao Xuan
Journal:  Fam Cancer       Date:  2015-03       Impact factor: 2.375

3.  Effect of Compound Zhebei Granule () combined with chemotherapy on surface markers of leukemia stem cell in patients with acute myeloid leukemia.

Authors:  Jing Wang; Zong-Lang Lai; Xin-Yi Chen; Dong-Yun Li; Ya-Yue Zhang; Wei Ma; Yu-Ting Chu; Feng-Qin Shi; Lu Yang; Li Hou
Journal:  Chin J Integr Med       Date:  2015-12-14       Impact factor: 1.978

4.  ALDH3A1 is overexpressed in a subset of hepatocellular carcinoma characterised by activation of the Wnt/ß-catenin pathway.

Authors:  Julien Calderaro; Jean-Charles Nault; Paulette Bioulac-Sage; Alexis Laurent; Jean-Frédéric Blanc; Thomas Decaens; Jessica Zucman-Rossi
Journal:  Virchows Arch       Date:  2013-11-26       Impact factor: 4.064

5.  Synergistic anti-leukemic activity of imatinib in combination with a small molecule Grb2 SH2 domain binding antagonist.

Authors:  M Zhang; Z Luo; H Liu; C M Croce; T R Burke; D P Bottaro
Journal:  Leukemia       Date:  2013-10-31       Impact factor: 11.528

6.  Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation.

Authors:  Beibei Zhang; Yasuhito Shimada; Junya Kuroyanagi; Noriko Umemoto; Yuhei Nishimura; Toshio Tanaka
Journal:  PLoS One       Date:  2014-01-15       Impact factor: 3.240

7.  Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1.

Authors:  Maura Gasparetto; Shanshan Pei; Mohammad Minhajuddin; Nabilah Khan; Daniel A Pollyea; Jason R Myers; John M Ashton; Michael W Becker; Vasilis Vasiliou; Keith R Humphries; Craig T Jordan; Clayton A Smith
Journal:  Haematologica       Date:  2017-03-09       Impact factor: 9.941

8.  Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors.

Authors:  Beibei Zhang; Yasuhito Shimada; Junya Kuroyanagi; Yuhei Nishimura; Noriko Umemoto; Tsuyoshi Nomoto; Taichi Shintou; Takeshi Miyazaki; Toshio Tanaka
Journal:  Tumour Biol       Date:  2014-09-11

9.  Cancer cell-soluble factors reprogram mesenchymal stromal cells to slow cycling, chemoresistant cells with a more stem-like state.

Authors:  Ahmed El-Badawy; Mohamed A Ghoneim; Mahmoud M Gabr; Radwa Ayman Salah; Ihab K Mohamed; Marwa Amer; Nagwa El-Badri
Journal:  Stem Cell Res Ther       Date:  2017-11-07       Impact factor: 6.832

10.  Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.

Authors:  Ja Young Kim-Muller; Jason Fan; Young Jung R Kim; Seung-Ah Lee; Emi Ishida; William S Blaner; Domenico Accili
Journal:  Nat Commun       Date:  2016-08-30       Impact factor: 14.919
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.