BACKGROUND: Ecological and experimental studies have suggested an increased risk of gastric cancer in relation to consumption of pickled vegetables in East Asia. METHODS: We conducted a meta-analysis of epidemiologic observational studies to evaluate the existing evidence. Searching PubMed, Vip Chinese Periodical, and China National Knowledge Infrastructure databases, we found a total of 60 studies, 50 case-control, and 10 prospective. We compared gastric cancer risk in pickled vegetable/food users versus nonusers (11 studies) or versus those in the lowest reported category of use (49 studies). Pooled results were computed with random-effects models. RESULTS: Among case-control studies, 30 showed significant increased risk and one showed significant decreased risk. Among prospective studies, two showed a significant increased risk but none showed a significant decreased risk. The OR (95% CI) was 1.52 (1.37-1.68) for the overall association, 1.56 (1.39-1.75) for case-control, and 1.32 (1.10-1.59) for cohort studies. The OR (95% CI) was 1.89 (1.29-2.77) in Korean, 1.86 (1.61-2.15) in Chinese, and 1.16 (1.04-1.29) in Japanese studies, and 1.14 (0.96-1.35) in studies from other countries. There was high heterogeneity in overall and subgroup analyses. There was little evidence for publication bias. CONCLUSION: Our results suggest a potential 50% higher risk of gastric cancer associated with intake of pickled vegetables/foods and perhaps stronger associations in Korea and China. IMPACT: The results of this study may offer ways to reduce the risk of gastric cancer in highly populated areas with high incidence of gastric cancer.
BACKGROUND: Ecological and experimental studies have suggested an increased risk of gastric cancer in relation to consumption of pickled vegetables in East Asia. METHODS: We conducted a meta-analysis of epidemiologic observational studies to evaluate the existing evidence. Searching PubMed, Vip Chinese Periodical, and China National Knowledge Infrastructure databases, we found a total of 60 studies, 50 case-control, and 10 prospective. We compared gastric cancer risk in pickled vegetable/food users versus nonusers (11 studies) or versus those in the lowest reported category of use (49 studies). Pooled results were computed with random-effects models. RESULTS: Among case-control studies, 30 showed significant increased risk and one showed significant decreased risk. Among prospective studies, two showed a significant increased risk but none showed a significant decreased risk. The OR (95% CI) was 1.52 (1.37-1.68) for the overall association, 1.56 (1.39-1.75) for case-control, and 1.32 (1.10-1.59) for cohort studies. The OR (95% CI) was 1.89 (1.29-2.77) in Korean, 1.86 (1.61-2.15) in Chinese, and 1.16 (1.04-1.29) in Japanese studies, and 1.14 (0.96-1.35) in studies from other countries. There was high heterogeneity in overall and subgroup analyses. There was little evidence for publication bias. CONCLUSION: Our results suggest a potential 50% higher risk of gastric cancer associated with intake of pickled vegetables/foods and perhaps stronger associations in Korea and China. IMPACT: The results of this study may offer ways to reduce the risk of gastric cancer in highly populated areas with high incidence of gastric cancer.
Authors: Haejin In; Marisa Langdon-Embry; Lauren Gordon; Clyde B Schechter; Judith Wylie-Rosett; Philip E Castle; M Margaret Kemeny; Bruce D Rapkin Journal: J Surg Res Date: 2018-04-03 Impact factor: 2.192
Authors: Joshua Petimar; Kathryn M Wilson; Kana Wu; Molin Wang; Demetrius Albanes; Piet A van den Brandt; Michael B Cook; Graham G Giles; Edward L Giovannucci; Gary E Goodman; Phyllis J Goodman; Niclas Håkansson; Kathy Helzlsouer; Timothy J Key; Laurence N Kolonel; Linda M Liao; Satu Männistö; Marjorie L McCullough; Roger L Milne; Marian L Neuhouser; Yikyung Park; Elizabeth A Platz; Elio Riboli; Norie Sawada; Jeannette M Schenk; Shoichiro Tsugane; Bas Verhage; Ying Wang; Lynne R Wilkens; Alicja Wolk; Regina G Ziegler; Stephanie A Smith-Warner Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-04-26 Impact factor: 4.254