INTRODUCTION: Myostatin (Mstn) is a secreted protein that acts as a negative regulator of skeletal muscle mass. However, a critical evaluation of neuromuscular aspects of hypertrophied muscles induced by Mstn deficiency has not been done. METHODS: We compared the tibialis anterior muscle-nerve interrelationships in wild-type and Mstn-null mice of both genders by immunohistochemical analyses, which allowed us to count the number of total axons and motor axons and estimate the size of motor units and the innervation ratio of the tibialis anterior muscle (TAm). RESULTS: There was an increase in the number of total axons and motor axons, and higher values in both the motor unit size and the innervation ratio of Mstn-null TAm compared with those of wild-type TAm. CONCLUSIONS: We found that myostatin is involved either directly in the control of neuromuscular interrelationships or indirectly through its effect on muscle size.
INTRODUCTION:Myostatin (Mstn) is a secreted protein that acts as a negative regulator of skeletal muscle mass. However, a critical evaluation of neuromuscular aspects of hypertrophied muscles induced by Mstn deficiency has not been done. METHODS: We compared the tibialis anterior muscle-nerve interrelationships in wild-type and Mstn-null mice of both genders by immunohistochemical analyses, which allowed us to count the number of total axons and motor axons and estimate the size of motor units and the innervation ratio of the tibialis anterior muscle (TAm). RESULTS: There was an increase in the number of total axons and motor axons, and higher values in both the motor unit size and the innervation ratio of Mstn-null TAm compared with those of wild-type TAm. CONCLUSIONS: We found that myostatin is involved either directly in the control of neuromuscular interrelationships or indirectly through its effect on muscle size.
Authors: Deepti Chugh; Chitra C Iyer; Prameela Bobbili; Anton J Blatnik; Brian K Kaspar; Kathrin Meyer; Arthur Hm Burghes; Brian C Clark; W David Arnold Journal: Neurobiol Aging Date: 2021-02-05 Impact factor: 4.673
Authors: Hrvoje Augustin; Kieran McGourty; Joern R Steinert; Helena M Cochemé; Jennifer Adcott; Melissa Cabecinha; Alec Vincent; Els F Halff; Josef T Kittler; Emmanuel Boucrot; Linda Partridge Journal: Development Date: 2017-05-22 Impact factor: 6.868
Authors: Esther Latres; Jeffrey Pangilinan; Lawrence Miloscio; Roy Bauerlein; Erqian Na; Terra B Potocky; Ying Huang; Mark Eckersdorff; Ashique Rafique; Jason Mastaitis; Calvin Lin; Andrew J Murphy; George D Yancopoulos; Jesper Gromada; Trevor Stitt Journal: Skelet Muscle Date: 2015-10-09 Impact factor: 4.912