Seward B Rutkove1, Matt C Gregas, Basil T Darras. 1. Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA. srutkove@bidmc.harvard.edu
Abstract
INTRODUCTION: New approaches for assessing disease progression in spinal muscular atrophy (SMA) are needed. In this study, we evaluate whether electrical impedance myography (EIM) can detect disease progression in SMA compared with a group of healthy children of similar age. METHODS: Twenty-eight children with SMA and 20 normal children underwent repeated EIM testing in four muscles at regular intervals for up to 3 years. An average rate of change of EIM was calculated for each subject and normalized to subcutaneous fat thickness and muscle girth. RESULTS: Multiple EIM parameters showed a change in normal subjects over a mean of 16.7 months; however, no change was found in SMA patients over this period. CONCLUSIONS: EIM could detect non-mass-dependent muscle maturation in healthy children. In contrast, the muscle in children with SMA, as measured by EIM, was virtually static, showing no evidence of growth or active deterioration.
INTRODUCTION: New approaches for assessing disease progression in spinal muscular atrophy (SMA) are needed. In this study, we evaluate whether electrical impedance myography (EIM) can detect disease progression in SMA compared with a group of healthy children of similar age. METHODS: Twenty-eight children with SMA and 20 normal children underwent repeated EIM testing in four muscles at regular intervals for up to 3 years. An average rate of change of EIM was calculated for each subject and normalized to subcutaneous fat thickness and muscle girth. RESULTS: Multiple EIM parameters showed a change in normal subjects over a mean of 16.7 months; however, no change was found in SMA patients over this period. CONCLUSIONS: EIM could detect non-mass-dependent muscle maturation in healthy children. In contrast, the muscle in children with SMA, as measured by EIM, was virtually static, showing no evidence of growth or active deterioration.
Authors: Jia Li; Tom R Geisbush; Glenn D Rosen; Jennifer Lachey; Aaron Mulivor; Seward B Rutkove Journal: Muscle Nerve Date: 2014-06 Impact factor: 3.217
Authors: Seward B Rutkove; Kush Kapur; Craig M Zaidman; Jim S Wu; Amy Pasternak; Lavanya Madabusi; Sung Yim; Adam Pacheck; Heather Szelag; Tim Harrington; Basil T Darras Journal: Ann Neurol Date: 2017-05-04 Impact factor: 10.422
Authors: Stefan Schwartz; Tom R Geisbush; Aleksandar Mijailovic; Amy Pasternak; Basil T Darras; Seward B Rutkove Journal: Clin Neurophysiol Date: 2014-05-17 Impact factor: 3.708
Authors: Seward B Rutkove; Tom R Geisbush; Aleksandar Mijailovic; Irina Shklyar; Amy Pasternak; Nicole Visyak; Jim S Wu; Craig Zaidman; Basil T Darras Journal: Pediatr Neurol Date: 2014-02-28 Impact factor: 3.372
Authors: Karlien Mul; Chad Heatwole; Katy Eichinger; Nuran Dilek; William B Martens; Baziel G M Van Engelen; Rabi Tawil; Jeffrey M Statland Journal: Muscle Nerve Date: 2018-04-17 Impact factor: 3.217
Authors: W Arnold; Vicki L McGovern; Benjamin Sanchez; Jia Li; Kaitlyn M Corlett; Stephen J Kolb; Seward B Rutkove; Arthur H Burghes Journal: Neurobiol Dis Date: 2015-12-28 Impact factor: 5.996