Gerald J Berry1. 1. Stanford University Medical Center, Stanford, California, USA. gjberry@stanford.edu
Abstract
PURPOSE OF REVIEW: The review will discuss the current pathological criteria for the diagnosis and classification of antibody-mediated rejection (AMR) in the cardiac allograft. RECENT FINDINGS: Until recently, the diagnosis of AMR required clinical dysfunction, presence of donor specific antibodies and pathological alterations. The concept of asymptomatic AMR and its adverse long-term outcomes created, in part the need to reevaluate diagnostic criteria. The results of a recent consensus meeting sponsored by International Society For Heart And Lung Transplantation are discussed. SUMMARY: The diagnosis of AMR rests on histopathological and immunophenotypic findings. These provide the basis for a new grading scheme.
PURPOSE OF REVIEW: The review will discuss the current pathological criteria for the diagnosis and classification of antibody-mediated rejection (AMR) in the cardiac allograft. RECENT FINDINGS: Until recently, the diagnosis of AMR required clinical dysfunction, presence of donor specific antibodies and pathological alterations. The concept of asymptomatic AMR and its adverse long-term outcomes created, in part the need to reevaluate diagnostic criteria. The results of a recent consensus meeting sponsored by International Society For Heart And Lung Transplantation are discussed. SUMMARY: The diagnosis of AMR rests on histopathological and immunophenotypic findings. These provide the basis for a new grading scheme.
Authors: P Bruneval; A Angelini; D Miller; L Potena; A Loupy; A Zeevi; E F Reed; D Dragun; N Reinsmoen; R N Smith; L West; S Tebutt; T Thum; M Haas; M Mengel; P Revelo; M Fedrigo; J P Duong Van Huyen; G J Berry Journal: Am J Transplant Date: 2016-12-12 Impact factor: 8.086