Literature DB >> 22498577

Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant?

P M M Moraes-Vieira1, E J Bassi, R C Araujo, N O S Câmara.   

Abstract

Food intake and nutritional status modify the physiological responses of the immune system to illness and infection and regulate the development of chronic inflammatory processes, such as kidney disease. Adipose tissue secretes immune-related proteins called adipokines that have pleiotropic effects on both the immune and neuroendocrine systems, linking metabolism and immune physiology. Leptin, an adipose tissue-derived adipokine, displays a variety of immune and physiological functions, and participates in several immune responses. Here, we review the current literature on the role of leptin in kidney diseases, linking adipose tissue and the immune system with kidney-related disorders. The modulation of this adipose hormone may have a major impact on the treatment of several immune- and metabolic-related kidney diseases.
© 2012 The Authors. obesity reviews © 2012 International Association for the Study of Obesity.

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Year:  2012        PMID： 22498577     DOI： 10.1111/j.1467-789X.2012.00997.x

Source DB:  PubMed          Journal:  Obes Rev        ISSN： 1467-7881            Impact factor:   9.213


  15 in total

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6.  Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells.

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9.  Exercise and caloric restriction alter the immune system of mice submitted to a high-fat diet.

Authors:  Frederick Wasinski; Reury F P Bacurau; Milton R Moraes; Anderson S Haro; Pedro M M Moraes-Vieira; Gabriel R Estrela; Edgar J Paredes-Gamero; Carlos C Barros; Sandro S Almeida; Niels O S Câmara; Ronaldo C Araujo
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Review 10.  Adipokines as drug targets in diabetes and underlying disturbances.

Authors:  Vinícius Andrade-Oliveira; Niels O S Câmara; Pedro M Moraes-Vieira
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