Diocésio A P de Andrade1, Jean-Pascal Machiels. 1. Department of Medical Oncology, Centre du Cancer, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Abstract
PURPOSE OF REVIEW: After multimodal treatment, 50-60% of patients with locally advanced squamous cell carcinoma of the head and neck will present locoregional and/or distant relapse within 2 years. This article will review chemotherapy and/or targeted agents as treatment options for patients who progress after platinum-based chemotherapy. RECENT FINDINGS: After years when the only therapeutic option was palliative chemotherapy, monoclonal antibodies targeting the epidermal growth factor receptor have emerged as new treatments. In particular, cetuximab and panitumumab have demonstrated progression-free survival and/or overall survival benefits in the first-line palliative treatment when given in combination with platinum-based chemotherapy. Recently, second-generation compounds (zalutumumab) or irreversible pan-human epidermal receptor (pan-HER) inhibitors have also shown promising activity after platinum failure. SUMMARY: Because median overall survival after platinum failure is less than 1 year, there is a clear requirement for new phase II/III studies with agents that have the potential to improve overall survival and quality of life. The previous use of platinum-based chemotherapy and the type of tumor response observed may substantially impact prognosis. Therefore, prior platinum use should be clearly defined in future clinical trials to enable a more accurate interpretation of the data.
PURPOSE OF REVIEW: After multimodal treatment, 50-60% of patients with locally advanced squamous cell carcinoma of the head and neck will present locoregional and/or distant relapse within 2 years. This article will review chemotherapy and/or targeted agents as treatment options for patients who progress after platinum-based chemotherapy. RECENT FINDINGS: After years when the only therapeutic option was palliative chemotherapy, monoclonal antibodies targeting the epidermal growth factor receptor have emerged as new treatments. In particular, cetuximab and panitumumab have demonstrated progression-free survival and/or overall survival benefits in the first-line palliative treatment when given in combination with platinum-based chemotherapy. Recently, second-generation compounds (zalutumumab) or irreversible pan-human epidermal receptor (pan-HER) inhibitors have also shown promising activity after platinum failure. SUMMARY: Because median overall survival after platinum failure is less than 1 year, there is a clear requirement for new phase II/III studies with agents that have the potential to improve overall survival and quality of life. The previous use of platinum-based chemotherapy and the type of tumor response observed may substantially impact prognosis. Therefore, prior platinum use should be clearly defined in future clinical trials to enable a more accurate interpretation of the data.
Authors: Vittal V S Kurisetty; Joshua Heiber; Rae Myers; Guilherme S Pereira; Jarrard W Goodwin; Mark J Federspiel; Stephen J Russell; Kah Whye Peng; Glen Barber; Jaime R Merchan Journal: Head Neck Date: 2014-02-01 Impact factor: 3.147
Authors: Maura L Gillison; George Blumenschein; Jerome Fayette; Joel Guigay; A Dimitrios Colevas; Lisa Licitra; Kevin J Harrington; Stefan Kasper; Everett E Vokes; Caroline Even; Francis Worden; Nabil F Saba; Lara Carmen Iglesias Docampo; Robert Haddad; Tamara Rordorf; Naomi Kiyota; Makoto Tahara; Manish Monga; Mark Lynch; Li Li; Robert L Ferris Journal: Oncologist Date: 2018-06-04