Literature DB >> 22498475

Mammalian PIK3C3/VPS34: the key to autophagic processing in liver and heart.

Nadia Jaber1, Zhixun Dou, Richard Z Lin, Jianhua Zhang, Wei-Xing Zong.   

Abstract

PIK3C3/Vps34 is the class III PtdIns3K that is evolutionarily conserved from yeast to mammals. Its central role in mammalian autophagy has been suggested through the use of pharmacological inhibitors and the study of its binding partners. However, the precise role of PIK3C3 in mammals is not clear. Using mouse strains that allow tissue-specific deletion of PIK3C3, we have described an essential role of PIK3C3 in regulating autophagy, and liver and heart function.

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Year:  2012        PMID： 22498475      PMCID： PMC3679090          DOI： 10.4161/auto.19627

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  14 in total

1.  FoxO1-AMPK-ULK1 Regulates Ethanol-Induced Autophagy in Muscle by Enhanced ATG14 Association with the BECN1-PIK3C3 Complex.

Authors:  Ly Q Hong-Brown; C Randell Brown; Maithili Navaratnarajah; Charles H Lang
Journal:  Alcohol Clin Exp Res       Date:  2017-04-05       Impact factor: 3.455

2.  Class III PI3K Biology.

Authors:  Manuella Caux; Gaetan Chicanne; Sonia Severin
Journal:  Curr Top Microbiol Immunol       Date:  2022       Impact factor: 4.737

3.  Insulin-dependent apolipoprotein B degradation is mediated by autophagy and involves class I and class III phosphatidylinositide 3-kinases.

Authors:  Janet D Sparks; Colleen O'Dell; Jeffrey M Chamberlain; Charles E Sparks
Journal:  Biochem Biophys Res Commun       Date:  2013-05-15       Impact factor: 3.575

4.  PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models.

Authors:  Nesrin Sabha; Jonathan R Volpatti; Hernan Gonorazky; Aaron Reifler; Ann E Davidson; Xingli Li; Nadine M Eltayeb; Claudia Dall'Armi; Gilbert Di Paolo; Susan V Brooks; Ana Buj-Bello; Eva L Feldman; James J Dowling
Journal:  J Clin Invest       Date:  2016-08-22       Impact factor: 14.808

Review 5.  Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease.

Authors:  Jianhua Zhang; Matilda Lillian Culp; Jason G Craver; Victor Darley-Usmar
Journal:  J Neurochem       Date:  2018-02-14       Impact factor: 5.372

Review 6.  Teaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approaches.

Authors:  Jianhua Zhang
Journal:  Redox Biol       Date:  2015-01-13       Impact factor: 11.799

7.  Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.

Authors:  Kelly Devereaux; Claudia Dall'Armi; Abel Alcazar-Roman; Yuta Ogasawara; Xiang Zhou; Fan Wang; Akitsugu Yamamoto; Pietro De Camilli; Gilbert Di Paolo
Journal:  PLoS One       Date:  2013-10-03       Impact factor: 3.240

8.  Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis.

Authors:  Mee-Sup Yoon; Jie Chen
Journal:  Mol Biol Cell       Date:  2013-09-25       Impact factor: 4.138

9.  Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts.

Authors:  Marlous J Groenewoud; Susan M I Goorden; Jorien Kassies; Wendy Pellis-van Berkel; Richard F Lamb; Ype Elgersma; Fried J T Zwartkruis
Journal:  PLoS One       Date:  2013-11-26       Impact factor: 3.240

Review 10.  The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases.

Authors:  Matthew Redmann; Victor Darley-Usmar; Jianhua Zhang
Journal:  Aging Dis       Date:  2016-03-15       Impact factor: 6.745
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