OBJECTIVE: The aim of this study was to investigate oxidative stress in ADHD children. DESIGN AND METHODS: Levels of oxidant parameters malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHDG), advanced oxidation protein products (AOPP) and antioxidant parameters paraoxonase (PON1) and thiol levels were measured in thirty children with ADHD (27 boys, 3 girls) who were firstly diagnosed according to DSM-IV and thirty healthy children (18 boys, 12 girls) aged 6-12 years. RESULTS: The levels of the oxidant parameters MDA and 8-OHDG were statistically significantly lower in ADHD children compared to the controls. We did not find a significant difference between the groups regarding AOPP, PON1, and thiol levels. CONCLUSION: We found low levels of some oxidants and no difference of antioxidant parameters in ADHD children. Our study points out that there may not be a direct relationship between oxidative stress and ADHD.
OBJECTIVE: The aim of this study was to investigate oxidative stress in ADHDchildren. DESIGN AND METHODS: Levels of oxidant parameters malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHDG), advanced oxidation protein products (AOPP) and antioxidant parameters paraoxonase (PON1) and thiol levels were measured in thirty children with ADHD (27 boys, 3 girls) who were firstly diagnosed according to DSM-IV and thirty healthy children (18 boys, 12 girls) aged 6-12 years. RESULTS: The levels of the oxidant parameters MDA and 8-OHDG were statistically significantly lower in ADHDchildren compared to the controls. We did not find a significant difference between the groups regarding AOPP, PON1, and thiol levels. CONCLUSION: We found low levels of some oxidants and no difference of antioxidant parameters in ADHDchildren. Our study points out that there may not be a direct relationship between oxidative stress and ADHD.
Authors: Asma Khan; Loek A W de Jong; Mary E Kamenski; Kerin K Higa; Jacinta D Lucero; Jared W Young; M Margarita Behrens; Susan B Powell Journal: Neuroscience Date: 2016-11-24 Impact factor: 3.590
Authors: Hamza Ayaydin; İsmail Akaltun; İsmail Koyuncu; Hakim Çelİk; Adnan Kİrmİt; Hatice Takatak Journal: Noro Psikiyatr Ars Date: 2020-09-21 Impact factor: 1.339