| Literature DB >> 22497794 |
Thomas W Mühleisen1, Manuel Mattheisen, Jana Strohmaier, Franziska Degenhardt, Lutz Priebe, C Christoph Schultz, René Breuer, Sandra Meier, Per Hoffmann, Fernando Rivandeneira, Albert Hofman, André G Uitterlinden, Susanne Moebus, Christian Gieger, Rebecca Emeny, Karl-Heinz Ladwig, H-Erich Wichmann, Markus Schwarz, Jutta Kammerer-Ciernioch, Ralf G M Schlösser, Igor Nenadic, Heinrich Sauer, Rainald Mössner, Wolfgang Maier, Dan Rujescu, Christoph Lange, Roel A Ophoff, Thomas G Schulze, Marcella Rietschel, Markus M Nöthen, Sven Cichon.
Abstract
A recent study found genome-wide significant association between common variation in the gene neurocan (NCAN, rs1064395) and bipolar disorder (BD). In view of accumulating evidence that BD and schizophrenia partly share genetic risk factors, we tested this single-nucleotide polymorphism for association with schizophrenia in three independent patient-control samples of European ancestry, totaling 5061 patients and 9655 controls. The rs1064395 A-allele, which confers risk for BD, was significantly over-represented in schizophrenia patients compared to controls (p=2.28×10(-3); odds ratio=1.11). Follow-up in non-overlapping samples from the Schizophrenia Psychiatric GWAS Consortium (5537 patients, 8043 controls) provided further support for our finding (p=0.0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22497794 DOI： 10.1016/j.schres.2012.03.007
Source DB: PubMed Journal: Schizophr Res ISSN： 0920-9964 Impact factor: 4.939