| Literature DB >> 2249682 |
D Pietrobon1, F Di Virgilio, T Pozzan.
Abstract
The maintenance of a low cytosolic free-Ca2+ concentration, ([Ca2+]i) is a common feature of all eukaryotic cells. For this purpose a variety of mechanisms have developed during evolution to ensure the buffering of Ca2+ in the cytoplasm, its extrusion from the cell and/or its accumulation within organelles. Opening of plasma membrane channels or release of Ca2+ from intracellular pools leads to elevation of [Ca2+]i; as a result, Ca2+ binds to cytosolic proteins which translate the changes in [Ca2+]i into activation of a number of key cellular functions. The purpose of this review is to provide a comprehensive description of the structural and functional characteristics of the various components of [Ca2+]i homeostasis in eukaryotes.Entities:
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Year: 1990 PMID: 2249682 DOI: 10.1111/j.1432-1033.1990.tb19378.x
Source DB: PubMed Journal: Eur J Biochem ISSN: 0014-2956