BACKGROUND: Functional outcome and quality of life (QOL) have become relevant endpoints in the field of laryngeal oncology, leading to the emergence of organ-preserving strategies. METHODS: The medical records of 166 patients with advanced (stages III and IV) laryngeal squamous cell carcinoma (SCC) who were treated with a total laryngectomy, radiochemotherapy, or cricohyoidopexy (CHP) were reviewed. RESULTS: In the whole series, no statistically significant differences among the 3 treatment arms with respect to the overall survival (OS) and disease-specific survival (DSS) rates were observed. The organ-preservation rate was 45% for radiotherapy and 76.7% for CHP (p = .0002). Among the cT4a cases, a longer survival was observed for the patients treated with total laryngectomy (3 yr-OS = 78% vs 68% for CHP and 54% for radiochemotherapy, p = .031). CONCLUSIONS: In advanced laryngeal SCC, CHP shows survival rates comparable to those of radiochemotherapy and a higher larynx-preservation rate, although it may not replace radiochemotherapy because it can be recommended only in selected cases.
BACKGROUND: Functional outcome and quality of life (QOL) have become relevant endpoints in the field of laryngeal oncology, leading to the emergence of organ-preserving strategies. METHODS: The medical records of 166 patients with advanced (stages III and IV) laryngeal squamous cell carcinoma (SCC) who were treated with a total laryngectomy, radiochemotherapy, or cricohyoidopexy (CHP) were reviewed. RESULTS: In the whole series, no statistically significant differences among the 3 treatment arms with respect to the overall survival (OS) and disease-specific survival (DSS) rates were observed. The organ-preservation rate was 45% for radiotherapy and 76.7% for CHP (p = .0002). Among the cT4a cases, a longer survival was observed for the patients treated with total laryngectomy (3 yr-OS = 78% vs 68% for CHP and 54% for radiochemotherapy, p = .031). CONCLUSIONS: In advanced laryngeal SCC, CHP shows survival rates comparable to those of radiochemotherapy and a higher larynx-preservation rate, although it may not replace radiochemotherapy because it can be recommended only in selected cases.
Authors: D De Seta; Flaminia Campo; V D'Aguanno; M Ralli; A Greco; F Y Russo; M de Vincentiis Journal: Lasers Med Sci Date: 2020-05-29 Impact factor: 3.161
Authors: C M Chiesa Estomba; F A Betances Reinoso; A I Lorenzo Lorenzo; J L Fariña Conde; J Araujo Nores; C Santidrian Hidalgo Journal: Acta Otorhinolaryngol Ital Date: 2016-12 Impact factor: 2.124
Authors: D Alterio; P Franco; G Numico; L Licitra; M Cossu Rocca; A Ferrari; C Pinto; E G Russi; U Ricardi; B A Jereczek Fossa Journal: Med Oncol Date: 2016-06-11 Impact factor: 3.064
Authors: A DE Virgilio; M Simonelli; A Greco; A Gallo; A Moretta; C C Wang; S Martellucci; P Calcagno; M DE Vincentiis Journal: Acta Otorhinolaryngol Ital Date: 2015-02 Impact factor: 2.124