BACKGROUND: Age-specific comparisons of influenza and respiratory syncytial virus (RSV) hospitalization rates can inform prevention efforts, including vaccine development plans. Previous US studies have not estimated jointly the burden of these viruses using similar data sources and over many seasons. METHODS: We estimated influenza and RSV hospitalizations in 5 age categories (<1, 1-4, 5-49, 50-64, and ≥65 years) with data for 13 states from 1993-1994 through 2007-2008. For each state and age group, we estimated the contribution of influenza and RSV to hospitalizations for respiratory and circulatory disease by using negative binomial regression models that incorporated weekly influenza and RSV surveillance data as covariates. RESULTS: Mean rates of influenza and RSV hospitalizations were 63.5 (95% confidence interval [CI], 37.5-237) and 55.3 (95% CI, 44.4-107) per 100000 person-years, respectively. The highest hospitalization rates for influenza were among persons aged ≥65 years (309/100000; 95% CI, 186-1100) and those aged <1 year (151/100000; 95% CI, 151-660). For RSV, children aged <1 year had the highest hospitalization rate (2350/100000; 95% CI, 2220-2520) followed by those aged 1-4 years (178/100000; 95% CI, 155-230). Age-standardized annual rates per 100000 person-years varied substantially for influenza (33-100) but less for RSV (42-77). CONCLUSIONS: Overall US hospitalization rates for influenza and RSV are similar; however, their age-specific burdens differ dramatically. Our estimates are consistent with those from previous studies focusing either on influenza or RSV. Our approach provides robust national comparisons of hospitalizations associated with these 2 viral respiratory pathogens by age group and over time.
BACKGROUND: Age-specific comparisons of influenza and respiratory syncytial virus (RSV) hospitalization rates can inform prevention efforts, including vaccine development plans. Previous US studies have not estimated jointly the burden of these viruses using similar data sources and over many seasons. METHODS: We estimated influenza and RSV hospitalizations in 5 age categories (<1, 1-4, 5-49, 50-64, and ≥65 years) with data for 13 states from 1993-1994 through 2007-2008. For each state and age group, we estimated the contribution of influenza and RSV to hospitalizations for respiratory and circulatory disease by using negative binomial regression models that incorporated weekly influenza and RSV surveillance data as covariates. RESULTS: Mean rates of influenza and RSV hospitalizations were 63.5 (95% confidence interval [CI], 37.5-237) and 55.3 (95% CI, 44.4-107) per 100000 person-years, respectively. The highest hospitalization rates for influenza were among persons aged ≥65 years (309/100000; 95% CI, 186-1100) and those aged <1 year (151/100000; 95% CI, 151-660). For RSV, children aged <1 year had the highest hospitalization rate (2350/100000; 95% CI, 2220-2520) followed by those aged 1-4 years (178/100000; 95% CI, 155-230). Age-standardized annual rates per 100000 person-years varied substantially for influenza (33-100) but less for RSV (42-77). CONCLUSIONS: Overall US hospitalization rates for influenza and RSV are similar; however, their age-specific burdens differ dramatically. Our estimates are consistent with those from previous studies focusing either on influenza or RSV. Our approach provides robust national comparisons of hospitalizations associated with these 2 viral respiratory pathogens by age group and over time.
Authors: H S Izurieta; W W Thompson; P Kramarz; D K Shay; R L Davis; F DeStefano; S Black; H Shinefield; K Fukuda Journal: N Engl J Med Date: 2000-01-27 Impact factor: 91.245
Authors: Marie R Griffin; Christopher S Coffey; Kathleen M Neuzil; Edward F Mitchel; Peter F Wright; Kathryn M Edwards Journal: Arch Intern Med Date: 2002-06-10
Authors: Harish Nair; D James Nokes; Bradford D Gessner; Mukesh Dherani; Shabir A Madhi; Rosalyn J Singleton; Katherine L O'Brien; Anna Roca; Peter F Wright; Nigel Bruce; Aruna Chandran; Evropi Theodoratou; Agustinus Sutanto; Endang R Sedyaningsih; Mwanajuma Ngama; Patrick K Munywoki; Cissy Kartasasmita; Eric A F Simões; Igor Rudan; Martin W Weber; Harry Campbell Journal: Lancet Date: 2010-05-01 Impact factor: 79.321
Authors: Alicia M Fry; Malinee Chittaganpitch; Henry C Baggett; Teresa C T Peret; Ryan K Dare; Pongpun Sawatwong; Somsak Thamthitiwat; Peera Areerat; Wichai Sanasuttipun; Julie Fischer; Susan A Maloney; Dean D Erdman; Sonja J Olsen Journal: PLoS One Date: 2010-11-30 Impact factor: 3.240
Authors: Rodica Gilca; Gaston De Serres; Danuta Skowronski; Guy Boivin; David L Buckeridge Journal: Am J Epidemiol Date: 2009-08-13 Impact factor: 4.897
Authors: Lin Yang; Susan S Chiu; King-Pan Chan; Kwok-Hung Chan; Wilfred Hing-Sang Wong; J S Malik Peiris; Chit-Ming Wong Journal: PLoS One Date: 2011-03-11 Impact factor: 3.240
Authors: Aurora Pop-Vicas; Momotazur Rahman; Pedro L Gozalo; Stefan Gravenstein; Vincent Mor Journal: J Am Geriatr Soc Date: 2015-08-17 Impact factor: 5.562
Authors: Andrea Gruneir; Jeff C Kwong; Michael A Campitelli; Alice Newman; Geoffrey M Anderson; Paula A Rochon; Vincent Mor Journal: Am J Public Health Date: 2013-12-12 Impact factor: 9.308
Authors: Kate Russell; Jessie R Chung; Arnold S Monto; Emily T Martin; Edward A Belongia; Huong Q McLean; Manjusha Gaglani; Kempapura Murthy; Richard K Zimmerman; Mary Patricia Nowalk; Michael L Jackson; Lisa A Jackson; Brendan Flannery Journal: Vaccine Date: 2018-02-28 Impact factor: 3.641
Authors: Christopher A Czaja; Lisa Miller; Nisha Alden; Heidi L Wald; Charisse Nitura Cummings; Melissa A Rolfes; Evan J Anderson; Nancy M Bennett; Laurie M Billing; Shua J Chai; Seth Eckel; Robert Mansmann; Melissa McMahon; Maya L Monroe; Alison Muse; Ilene Risk; William Schaffner; Ann R Thomas; Kimberly Yousey-Hindes; Shikha Garg; Rachel K Herlihy Journal: Open Forum Infect Dis Date: 2019-07-01 Impact factor: 3.835
Authors: Edward E Walsh; Lu Wang; Ann R Falsey; Xing Qiu; Anthony Corbett; Jeanne Holden-Wiltse; Thomas J Mariani; David J Topham; Mary T Caserta Journal: J Infect Dis Date: 2018-06-20 Impact factor: 5.226