BACKGROUND: Secretory carcinoma of the breast is a rare breast cancer that is associated with incidence at a young age and an indolent course. The role for breast conservation and adjuvant radiation is unknown. METHODS: The SEER database was reviewed and 83 patients were identified with secretory carcinoma of the breast between the years 1983 and 2007. Baseline characteristics were compared with χ(2) or Fisher's exact test. Overall survival (OS) and cause-specific survival (CSS) were estimated using the Kaplan-Meier method. Analyses were performed using PASW Statistics, version 18. RESULTS: Median follow-up was 70 months. Median patient age was 53 years (range 11-86 years). 29 patients (34.9%) had involved regional lymph nodes. 39 patients (47.0%) underwent lumpectomy and 44 patients (53.0%) underwent mastectomy. 35 patients (42.2%) received radiation. Patients receiving radiation were more likely to have undergone lumpectomy, and the use of radiation increased over time. 5-year OS was 87.2%; 10-year OS was 76.5%. 5-year CSS was 94.4%; 10-year CSS was 91.4%. Among the lumpectomy patients, 25 patients (64.1%) received radiation. For lumpectomy patients, those who did not receive radiation had a 5-year OS of 92.9% and 10-year OS of 72.2% while patients who did receive radiation had a 5-year OS of 95.5% and 10-year OS of 85.9%. Only 1 patient treated with lumpectomy only died of cancer (92.9% CSS) and no patients treated with lumpectomy and radiation died of cancer (100% CSS). CONCLUSIONS: Secretory carcinoma of the breast commonly occurs at a later age than previously recognized, and is associated with good long-term survival.
BACKGROUND: Secretory carcinoma of the breast is a rare breast cancer that is associated with incidence at a young age and an indolent course. The role for breast conservation and adjuvant radiation is unknown. METHODS: The SEER database was reviewed and 83 patients were identified with secretory carcinoma of the breast between the years 1983 and 2007. Baseline characteristics were compared with χ(2) or Fisher's exact test. Overall survival (OS) and cause-specific survival (CSS) were estimated using the Kaplan-Meier method. Analyses were performed using PASW Statistics, version 18. RESULTS: Median follow-up was 70 months. Median patient age was 53 years (range 11-86 years). 29 patients (34.9%) had involved regional lymph nodes. 39 patients (47.0%) underwent lumpectomy and 44 patients (53.0%) underwent mastectomy. 35 patients (42.2%) received radiation. Patients receiving radiation were more likely to have undergone lumpectomy, and the use of radiation increased over time. 5-year OS was 87.2%; 10-year OS was 76.5%. 5-year CSS was 94.4%; 10-year CSS was 91.4%. Among the lumpectomy patients, 25 patients (64.1%) received radiation. For lumpectomy patients, those who did not receive radiation had a 5-year OS of 92.9% and 10-year OS of 72.2% while patients who did receive radiation had a 5-year OS of 95.5% and 10-year OS of 85.9%. Only 1 patient treated with lumpectomy only died of cancer (92.9% CSS) and no patients treated with lumpectomy and radiation died of cancer (100% CSS). CONCLUSIONS: Secretory carcinoma of the breast commonly occurs at a later age than previously recognized, and is associated with good long-term survival.
Authors: Neerav Shukla; Stephen S Roberts; Mollah O Baki; Qazi Mushtaq; Paul E Goss; Ben H Park; Gunes Gundem; Ken Tian; Heather Geiger; Kristie Redfield; Gerald Behr; Ryma Benayed; Ahmet Zehir; Jaclyn F Hechtman; Robert B Darnell; Elli Papaemmanuil; Marc Ladanyi; Nora Ku; Andrew L Kung; José Baselga; Alexander Drilon; David M Hyman Journal: JCO Precis Oncol Date: 2017-08-18
Authors: Felipe C Geyer; Fresia Pareja; Britta Weigelt; Emad Rakha; Ian O Ellis; Stuart J Schnitt; Jorge S Reis-Filho Journal: Am J Pathol Date: 2017-07-20 Impact factor: 4.307
Authors: Gregor Krings; Nancy M Joseph; Gregory R Bean; David Solomon; Courtney Onodera; Eric Talevich; Iwei Yeh; James P Grenert; Elizabeth Hosfield; Emily D Crawford; Richard C Jordan; Annemieke van Zante; Charles Zaloudek; Sandra J Shin; Yunn-Yi Chen Journal: Mod Pathol Date: 2017-05-26 Impact factor: 7.842