BACKGROUND: Atherosclerosis, endothelial dysfunction, coronary artery calcification (CAC), and left ventricular hypertrophy are the most commonly encountered risk factors in the pathogenesis of cardiovascular disease in end-stage renal disease patients. Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease and EAT has been shown in healthy subjects and patients with a high risk of coronary artery disease. In the present study, we aimed to investigate the relationship between EAT and CAC in peritoneal dialysis (PD) patients. Patients and Methods: Forty-five PD patients (18 females, 27 males, with a mean age of 50.6 ± 15 years) and 25 healthy subjects (12 females, 13 males, with a mean age of 52.4 ± 10.7 years) were enrolled in the study. EAT and CAC score (CACS) measurements were performed by a multidetector computed tomography scanner. RESULTS: EAT of the PD patients was significantly higher than that of the healthy subjects (p = 0.02). When patients were divided into two subgroups (group 1: CACS ≤10, n = 20; group 2: CACS >10, n = 25), EAT was also significantly higher in group 2 patients than in group 1 patients and healthy subjects. Age and EAT were also found to be correlated with CACS ≥10. CONCLUSION: There is a relationship between the anatomic assessment of coronary artery lesions by multidetector computed tomography and EAT in PD patients. This relationship might be attributed to increased inflammation and proinflammatory cytokines in uremic patients.
BACKGROUND:Atherosclerosis, endothelial dysfunction, coronary artery calcification (CAC), and left ventricular hypertrophy are the most commonly encountered risk factors in the pathogenesis of cardiovascular disease in end-stage renal diseasepatients. Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease and EAT has been shown in healthy subjects and patients with a high risk of coronary artery disease. In the present study, we aimed to investigate the relationship between EAT and CAC in peritoneal dialysis (PD) patients. Patients and Methods: Forty-five PDpatients (18 females, 27 males, with a mean age of 50.6 ± 15 years) and 25 healthy subjects (12 females, 13 males, with a mean age of 52.4 ± 10.7 years) were enrolled in the study. EAT and CAC score (CACS) measurements were performed by a multidetector computed tomography scanner. RESULTS: EAT of the PDpatients was significantly higher than that of the healthy subjects (p = 0.02). When patients were divided into two subgroups (group 1: CACS ≤10, n = 20; group 2: CACS >10, n = 25), EAT was also significantly higher in group 2 patients than in group 1 patients and healthy subjects. Age and EAT were also found to be correlated with CACS ≥10. CONCLUSION: There is a relationship between the anatomic assessment of coronary artery lesions by multidetector computed tomography and EAT in PDpatients. This relationship might be attributed to increased inflammation and proinflammatory cytokines in uremic patients.
Authors: Guido A Rosito; Joseph M Massaro; Udo Hoffmann; Frederick L Ruberg; Amir A Mahabadi; Ramachandran S Vasan; Christopher J O'Donnell; Caroline S Fox Journal: Circulation Date: 2008-01-22 Impact factor: 29.690
Authors: Emin Murat Akbas; Levent Demirtas; Adalet Ozcicek; Aysu Timuroglu; Eftal Murat Bakirci; Hikmet Hamur; Fatih Ozcicek; Kultigin Turkmen Journal: Int J Clin Exp Med Date: 2014-07-15
Authors: K Turkmen; H Z Tonbul; F M Erdur; I Guney; H Kayikcioglu; L Altintepe; O Ozbek; M I Yilmaz; A Gaipov; S Turk; A Covic; M Kanbay Journal: Int Urol Nephrol Date: 2012-09-23 Impact factor: 2.370
Authors: Paulo H N Harada; Maria E Canziani; Leonardo M Lima; Maria Kamimura; Carlos E Rochitte; Marcelo M Lemos; Lilian Cuppari; Roberto Kalil Filho; Sergio A Draibe; Raul D Santos Journal: PLoS One Date: 2014-12-05 Impact factor: 3.240