Literature DB >> 22492850

Effects of short-course zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine.

Mark A Micek1, Ana Judith Blanco, Jacquelyn Carlsson, Ingrid A Beck, Sandra Dross, Laurinda Matunha, Kristy Seidel, Pablo Montoya, Soren Gantt, Eduardo Matediana, Lilia Jamisse, Stephen Gloyd, Lisa M Frenkel.   

Abstract

Single-dose nevirapine (sdNVP) given to prevent mother-to-child-transmission of HIV-1 selects NVP-resistance. Short-course zidovudine (ZDV) was hypothesized to lower rates of NVP-resistance. HIV-1 infected pregnant women administered sdNVP with or without short-course ZDV were assessed for HIV-1 mutations (K103N, Y181C, G190A, and V106M) prior to delivery and postpartum. Postpartum NVP-resistance was lower among 31 taking ZDV+sdNVP compared to 33 taking only sdNVP (35.5% vs. 72.7%; χ2 P = .003). NVP mutants decayed to <2% in 24/35 (68.6%) at a median 6 months postpartum, with no differences based on ZDV use (logrank P = .99). Short-course ZDV was associated with reduced NVP-resistance mutations among women taking sdNVP.

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Year:  2012        PMID： 22492850      PMCID： PMC3415891          DOI： 10.1093/infdis/jis282

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  13 in total

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Authors:  C A Boucher; E O'Sullivan; J W Mulder; C Ramautarsing; P Kellam; G Darby; J M Lange; J Goudsmit; B A Larder
Journal:  J Infect Dis       Date:  1992-01       Impact factor: 5.226

2.  Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana.

Authors:  Roger L Shapiro; Ibou Thior; Peter B Gilbert; Shahin Lockman; Carolyn Wester; Laura M Smeaton; Lisa Stevens; S Jody Heymann; Thumbi Ndung'u; Simani Gaseitsiwe; Vladimir Novitsky; Joseph Makhema; Stephen Lagakos; Max Essex
Journal:  AIDS       Date:  2006-06-12       Impact factor: 4.177

3.  Addition of 7 days of zidovudine plus lamivudine to peripartum single-dose nevirapine effectively reduces nevirapine resistance postpartum in HIV-infected mothers in Malawi.

Authors:  Sherry L Farr; Julie A E Nelson; Thokozani J Ng'ombe; Athena P Kourtis; Charles Chasela; Jeffrey A Johnson; Angela D M Kashuba; Gerald L Tegha; Jeffrey Wiener; Joseph J Eron; Harriet N Banda; Mwanangwa Mpaso; Jonathan Lipscomb; Chrissie Matiki; Susan A Fiscus; Denise J Jamieson; Charles van der Horst
Journal:  J Acquir Immune Defic Syndr       Date:  2010-08       Impact factor: 3.731

4.  Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission.

Authors:  S Palmer; V Boltz; N Martinson; F Maldarelli; G Gray; J McIntyre; J Mellors; L Morris; J Coffin
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-25       Impact factor: 11.205

5.  Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012).

Authors:  S H Eshleman; M Mracna; L A Guay; M Deseyve; S Cunningham; M Mirochnick; P Musoke; T Fleming; M Glenn Fowler; L M Mofenson; F Mmiro; J B Jackson
Journal:  AIDS       Date:  2001-10-19       Impact factor: 4.177

6.  Single-dose perinatal nevirapine plus standard zidovudine to prevent mother-to-child transmission of HIV-1 in Thailand.

Authors:  Marc Lallemant; Gonzague Jourdain; Sophie Le Coeur; Jean Yves Mary; Nicole Ngo-Giang-Huong; Suporn Koetsawang; Siripon Kanshana; Kenneth McIntosh; Vallop Thaineua
Journal:  N Engl J Med       Date:  2004-07-09       Impact factor: 91.245

7.  Intrapartum exposure to nevirapine and subsequent maternal responses to nevirapine-based antiretroviral therapy.

Authors:  Gonzague Jourdain; Nicole Ngo-Giang-Huong; Sophie Le Coeur; Chureeratana Bowonwatanuwong; Pacharee Kantipong; Pranee Leechanachai; Surabhon Ariyadej; Prattana Leenasirimakul; Scott Hammer; Marc Lallemant
Journal:  N Engl J Med       Date:  2004-07-09       Impact factor: 91.245

8.  Zidovudine with nevirapine for the prevention of HIV mother-to-child transmission reduces nevirapine resistance in mothers from the Western Cape, South Africa.

Authors:  G U van Zyl; M Claassen; S Engelbrecht; J D Laten; M F Cotton; G B Theron; W Preiser
Journal:  J Med Virol       Date:  2008-06       Impact factor: 2.327

9.  Lower risk of resistance after short-course HAART compared with zidovudine/single-dose nevirapine used for prevention of HIV-1 mother-to-child transmission.

Authors:  Dara A Lehman; Michael H Chung; Jennifer M Mabuka; Grace C John-Stewart; James Kiarie; John Kinuthia; Julie Overbaugh
Journal:  J Acquir Immune Defic Syndr       Date:  2009-08-15       Impact factor: 3.731

10.  Efficacy of short-course AZT plus 3TC to reduce nevirapine resistance in the prevention of mother-to-child HIV transmission: a randomized clinical trial.

Authors:  James A McIntyre; Mark Hopley; Daya Moodley; Marie Eklund; Glenda E Gray; David B Hall; Patrick Robinson; Douglas Mayers; Neil A Martinson
Journal:  PLoS Med       Date:  2009-10-27       Impact factor: 11.069
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  5 in total

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Authors:  Ross S Milne; Rachel A Silverman; Ingrid A Beck; Jennifer Mckernan-Mullin; Wenjie Deng; Thomas R Sibley; Sandra Dross; James N Kiarie; Samah R Sakr; Robert W Coombs; Michael H Chung; Lisa M Frenkel
Journal:  AIDS       Date:  2019-05-01       Impact factor: 4.177

2.  Clinical implications of HIV-1 minority variants.

Authors:  Jonathan Z Li; Daniel R Kuritzkes
Journal:  Clin Infect Dis       Date:  2013-02-27       Impact factor: 9.079

Review 3.  Impact of antiretroviral drugs in pregnant women and their children in Africa: HIV resistance and treatment outcomes.

Authors:  Roger Paredes; Vincent C Marconi; Shahin Lockman; Elaine J Abrams; Louise Kuhn
Journal:  J Infect Dis       Date:  2013-06-15       Impact factor: 5.226

4.  Nevirapine-Resistant HIV-1 DNA in Breast Milk After Single-Dose Nevirapine With or Without Zidovudine for Prevention of Mother-to-Child Transmission.

Authors:  Soren Gantt; Rachel Payant; Jacquelyn Carlsson; Mark A Micek; Ana Judith Blanco; Ingrid A Beck; Laurinda Matunha; Pablo Montoya; Eduardo Matediana; Stephen Gloyd; Lisa M Frenkel
Journal:  J Pediatric Infect Dis Soc       Date:  2012-07-03       Impact factor: 3.164

5.  Correlates of HIV detection among breastfeeding postpartum Kenyan women eligible under Option B.

Authors:  Mary Chan; Eric Munene Muriuki; Sandra Emery; Ruth Kanthula; Vrasha Chohan; Lisa M Frenkel; Anna Wald; Bhavna Chohan; Julie Overbaugh; Alison C Roxby
Journal:  PLoS One       Date:  2019-05-31       Impact factor: 3.240
  5 in total

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