Literature DB >> 2249249

Resistance to cadmium is under control of the CAD2 gene in the yeast Saccharomyces cerevisiae.

H Tohoyama1, M Inouhe, M Joho, T Murayama.   

Abstract

A cadmium-resistant strain, X3382-3A, which is able to grow in a medium containing 0.2 mM cadmium sulfate, was picked out from our laboratory stock strains of Saccharomyces cerevisiae. The cadmium resistance of this strain is controlled by a single dominant nuclear gene, denoted as CAD2. The locus of CAD2 was mapped by gene linkage to a site 15.5 centimorgans to the right of the his7 locus on the right arm of chromosome II. The cadmium resistance of the strain carrying CAD2 was evaluated for its properties of cadmium uptake, cadmium distribution and cadmium-metallothionein formation, in comparison with those of some other strains. The results suggest that the novel type of cadmium resistance controlled by CAD2 does ot involve production of a cadmium-metallothionein.

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Year:  1990        PMID： 2249249     DOI： 10.1007/bf00318377

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  9 in total

1.  Gene control of resistance vs sensitivity to cadmium in saccharomyces.

Authors:  S HINO; C C LINDEGREN; G LINDEGREN; J E MIDDLEKAUFF; S P YANG
Journal:  J Bacteriol       Date:  1956-12       Impact factor: 3.490

2.  Role of cell wall in Saccharomyces cerevisiae mutants resistant to Hg2+.

Authors:  B Ono; H Ohue; F Ishihara
Journal:  J Bacteriol       Date:  1988-12       Impact factor: 3.490

3.  Genetic map of Saccharomyces cerevisiae, edition 10.

Authors:  R K Mortimer; D Schild; C R Contopoulou; J A Kans
Journal:  Yeast       Date:  1989 Sep-Oct       Impact factor: 3.239

Review 4.  Biochemical effects of mercury, cadmium, and lead.

Authors:  B L Vallee; D D Ulmer
Journal:  Annu Rev Biochem       Date:  1972       Impact factor: 23.643

5.  Tandem gene amplification mediates copper resistance in yeast.

Authors:  S Fogel; J W Welch
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

6.  Cadmium-binding protein in a cadmium-resistant strain of Saccharomyces cerevisiae.

Authors:  M Inouhe; M Hiyama; H Tohoyama; M Joho; T Murayama
Journal:  Biochim Biophys Acta       Date:  1989-10-13

7.  Cloning and expression of a yeast copper metallothionein gene.

Authors:  T R Butt; E Sternberg; J Herd; S T Crooke
Journal:  Gene       Date:  1984-01       Impact factor: 3.688

8.  Yeast metallothionein. Sequence and metal-binding properties.

Authors:  D R Winge; K B Nielson; W R Gray; D H Hamer
Journal:  J Biol Chem       Date:  1985-11-25       Impact factor: 5.157

9.  Phenotype character of the methylglyoxal resistance gene in Saccharomyces cerevisiae: expression in Escherichia coli and application to breeding wild-type yeast strains.

Authors:  K Murata; Y Fukuda; M Shimosaka; K Watanabe; T Saikusa; A Kimura
Journal:  Appl Environ Microbiol       Date:  1985-11       Impact factor: 4.792
  9 in total
  2 in total

1.  Saccharomyces cerevisiae and Neurospora crassa contain heavy metal sequestering phytochelatin.

Authors:  R Kneer; T M Kutchan; A Hochberger; M H Zenk
Journal:  Arch Microbiol       Date:  1992       Impact factor: 2.552

2.  The gene for cadmium metallothionein from a cadmium-resistant yeast appears to be identical to CUP1 in a copper-resistant strain.

Authors:  H Tohoyama; T Tomoyasu; M Inouhe; M Joho; T Murayama
Journal:  Curr Genet       Date:  1992-04       Impact factor: 3.886
  2 in total

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