OBJECTIVE: Several small to medium-sized studies indicated a link between cervical artery dissection (CeAD) and migraine. Migrainous CeAD patients were suggested to have different clinical characteristics compared to nonmigraine CeAD patients. We tested these hypotheses in the large Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) population. METHODS: A total of 968 CeAD patients and 653 patients with an ischemic stroke of a cause other than CeAD (non-CeAD IS) were recruited. CeAD patients with stroke (CeAD(stroke), n = 635) were compared with non-CeAD IS patients regarding migraine, clinical characteristics, and outcome. CeAD patients with and without migraine were compared in terms of clinical characteristics and outcome. RESULTS: Migraine was more common among CeAD(stroke) patients compared to non-CeAD IS patients (35.7 vs 27.4%, p = 0.003). The difference was mainly due to migraine without aura (20.2 vs 11.2%, p < 0.001). There were no differences in prevalence of strokes, arterial distribution, or other clinical or prognostic features between migrainous and nonmigrainous CeAD patients. CONCLUSION: Migraine without aura is more common among CeAD(stroke) patients compared to non-CeAD IS patients. The mechanisms and possible causative link remain to be proved. Although CeAD is often complicated by stroke, our data do not support increased risk of stroke in migrainous CeAD patients.
OBJECTIVE: Several small to medium-sized studies indicated a link between cervical artery dissection (CeAD) and migraine. Migrainous CeADpatients were suggested to have different clinical characteristics compared to nonmigraine CeAD patients. We tested these hypotheses in the large Cervical Artery Dissection and Ischemic StrokePatients (CADISP) population. METHODS: A total of 968 CeAD patients and 653 patients with an ischemic stroke of a cause other than CeAD (non-CeAD IS) were recruited. CeAD patients with stroke (CeAD(stroke), n = 635) were compared with non-CeAD IS patients regarding migraine, clinical characteristics, and outcome. CeAD patients with and without migraine were compared in terms of clinical characteristics and outcome. RESULTS:Migraine was more common among CeAD(stroke) patients compared to non-CeAD IS patients (35.7 vs 27.4%, p = 0.003). The difference was mainly due to migraine without aura (20.2 vs 11.2%, p < 0.001). There were no differences in prevalence of strokes, arterial distribution, or other clinical or prognostic features between migrainous and nonmigrainous CeAD patients. CONCLUSION:Migraine without aura is more common among CeAD(stroke) patients compared to non-CeAD IS patients. The mechanisms and possible causative link remain to be proved. Although CeAD is often complicated by stroke, our data do not support increased risk of stroke in migrainous CeADpatients.
Authors: Stéphanie Debette; Yoichiro Kamatani; Tiina M Metso; Manja Kloss; Ganesh Chauhan; Stefan T Engelter; Alessandro Pezzini; Vincent Thijs; Hugh S Markus; Martin Dichgans; Christiane Wolf; Ralf Dittrich; Emmanuel Touzé; Andrew M Southerland; Yves Samson; Shérine Abboud; Yannick Béjot; Valeria Caso; Anna Bersano; Andreas Gschwendtner; Maria Sessa; John Cole; Chantal Lamy; Elisabeth Medeiros; Simone Beretta; Leo H Bonati; Armin J Grau; Patrik Michel; Jennifer J Majersik; Pankaj Sharma; Ludmila Kalashnikova; Maria Nazarova; Larisa Dobrynina; Eva Bartels; Benoit Guillon; Evita G van den Herik; Israel Fernandez-Cadenas; Katarina Jood; Michael A Nalls; Frank-Erik De Leeuw; Christina Jern; Yu-Ching Cheng; Inge Werner; Antti J Metso; Christoph Lichy; Philippe A Lyrer; Tobias Brandt; Giorgio B Boncoraglio; Heinz-Erich Wichmann; Christian Gieger; Andrew D Johnson; Thomas Böttcher; Maurizio Castellano; Dominique Arveiler; M Arfan Ikram; Monique M B Breteler; Alessandro Padovani; James F Meschia; Gregor Kuhlenbäumer; Arndt Rolfs; Bradford B Worrall; Erich-Bernd Ringelstein; Diana Zelenika; Turgut Tatlisumak; Mark Lathrop; Didier Leys; Philippe Amouyel; Jean Dallongeville Journal: Nat Genet Date: 2014-11-24 Impact factor: 38.330
Authors: D D Mitsikostas; M Ashina; A Craven; H C Diener; P J Goadsby; M D Ferrari; C Lampl; K Paemeleire; J Pascual; A Siva; J Olesen; V Osipova; P Martelletti Journal: J Headache Pain Date: 2016-02-09 Impact factor: 7.277
Authors: Elbert H Witvoet; Nadine Pelzer; Gisela M Terwindt; Gabriël J E Rinkel; Monique H M Vlak; Ale Algra; Marieke J H Wermer Journal: Brain Behav Date: 2017-03-30 Impact factor: 2.708