Literature DB >> 22491689

"tet(U)" is not a tetracycline resistance determinant.

Jamie A Caryl1, Georgina Cox, Stefan Trimble, Alex J O'Neill.   

Abstract

The enterococcal plasmid pKQ10 has been reported to carry a poorly characterized tetracycline resistance determinant designated tet(U). However, in a series of studies intended to further characterize this determinant, we have been unable to substantiate the claim that tet(U) confers resistance to tetracyclines. In line with these results, bioinformatic analysis provides compelling evidence that "tet(U)" is in fact the misannotated 3' end of a gene encoding a rolling-circle replication initiator (Rep) protein.

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Year:  2012        PMID： 22491689      PMCID： PMC3370814          DOI： 10.1128/AAC.05957-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

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Review 3.  Rolling-circle replication of bacterial plasmids.

Authors:  S A Khan
Journal:  Microbiol Mol Biol Rev       Date:  1997-12       Impact factor: 11.056

4.  A novel tetracycline-resistant determinant, tet(U), is encoded on the plasmid pKq10 in Enterococcus faecium.

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9.  Purification and characterization of Tet(M), a protein that renders ribosomes resistant to tetracycline.

Authors:  V Burdett
Journal:  J Biol Chem       Date:  1991-02-15       Impact factor: 5.157
  9 in total
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  6 in total

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