| Literature DB >> 22489548 |
Kerstin Rohr1, Rainer Mahrwald.
Abstract
Isoleucine-catalyzed direct enantioselective aldol additions between enolizable aldehydes are reported. Intermediate acetal structures dictate the configurative outcome and were supported by a hydrogen bond. This direct isoleucine-catalyzed aldol addition represents a welcome complement to both proline- and histidine-catalyzed aldol additions of enolizable aldehydes.Entities:
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Year: 2012 PMID： 22489548 DOI： 10.1021/ol300754n
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005