OBJECTIVE: Assess the relative effects of a variety of illicit and licit drugs on risk for adverse birth outcomes. METHODS: We used data from two large prospective investigations, and a novel analytic method, recursive partitioning class analysis to identify risk factors associated with preterm birth and delivering a small for gestational age infant. RESULTS: Compared to cocaine and opiate non-users, cocaine users were 3.53 times as likely (95% CI: 1.65-7.56; p = 0.001) and opiate users 2.86 times as likely (95% CI: 1.11-7.36; p = 0.03) to deliver preterm. The odds of delivering a small for gestational age infant for women who smoked more than two cigarettes daily was 3.74, (95% CI: 2.47-5.65; p<0.0001) compared to women who smoked two or less cigarettes daily and had one previous child. Similarly, less educated, nulliparous women who smoked two or fewer cigarettes daily were 4.12 times as likely (95% CI: 2.04-8.34; p < 0.0001) to have a small for gestational age infant. CONCLUSIONS: Among our covariates, prenatal cocaine and opiate use are the predominant risk factors for preterm birth; while tobacco use was the primary risk factor predicting small for gestational age at delivery. Multi-substance use did not substantially increase risk of adverse birth outcomes over these risk factors.
OBJECTIVE: Assess the relative effects of a variety of illicit and licit drugs on risk for adverse birth outcomes. METHODS: We used data from two large prospective investigations, and a novel analytic method, recursive partitioning class analysis to identify risk factors associated with preterm birth and delivering a small for gestational age infant. RESULTS: Compared to cocaine and opiate non-users, cocaine users were 3.53 times as likely (95% CI: 1.65-7.56; p = 0.001) and opiate users 2.86 times as likely (95% CI: 1.11-7.36; p = 0.03) to deliver preterm. The odds of delivering a small for gestational age infant for women who smoked more than two cigarettes daily was 3.74, (95% CI: 2.47-5.65; p<0.0001) compared to women who smoked two or less cigarettes daily and had one previous child. Similarly, less educated, nulliparous women who smoked two or fewer cigarettes daily were 4.12 times as likely (95% CI: 2.04-8.34; p < 0.0001) to have a small for gestational age infant. CONCLUSIONS: Among our covariates, prenatal cocaine and opiate use are the predominant risk factors for preterm birth; while tobacco use was the primary risk factor predicting small for gestational age at delivery. Multi-substance use did not substantially increase risk of adverse birth outcomes over these risk factors.
Authors: Henrietta S Bada; Abhik Das; Charles R Bauer; Seetha Shankaran; Barry Lester; Linda L Wright; Joel Verter; Vincent L Smeriglio; Loretta P Finnegan; Penelope L Maza Journal: Obstet Gynecol Date: 2002-11 Impact factor: 7.661
Authors: Ayman El-Mohandes; Allen A Herman; M Nabil El-Khorazaty; Pragathi S Katta; Davene White; Lawrence Grylack Journal: J Perinatol Date: 2003 Jul-Aug Impact factor: 2.521
Authors: Susanna R Magee; Margaret H Bublitz; Christina Orazine; Bridget Brush; Amy Salisbury; Raymond Niaura; Laura R Stroud Journal: Matern Child Health J Date: 2014-05
Authors: Monica R McLemore; Rachel L Berkowitz; Scott P Oltman; Rebecca J Baer; Linda Franck; Jonathan Fuchs; Deborah A Karasek; Miriam Kuppermann; Safyer McKenzie-Sampson; Daphina Melbourne; Briane Taylor; Shanell Williams; Larry Rand; Brittany D Chambers; Karen Scott; Laura L Jelliffe-Pawlowski Journal: J Racial Ethn Health Disparities Date: 2020-10-09